Varaico: Literature-Extracted Genetic Variants

Gene:SIAH1
Variant:p.C44S
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SIAH1

NM_003031.4:p.C44S

Associated Papers

SIAH1 ubiquitin ligase mediates ubiquitination and degradation of Akt3 in neural development.

Ko HR et al.

The Journal of Biological Chemistry, 2019

Zyxin is a critical regulator of the apoptotic HIPK2-p53 signaling axis.

Crone J et al.

Cancer Research, 2011

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.

Winter M et al.

Nature Cell Biology, 2008

Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.

Hu G et al.

Molecular and Cellular Biology, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."