Associated Papers
Sirtuin 1 inhibits NLRP3 inflammasome activation through protein-protein interaction.
Ho LC et al.
Life Sciences, 2026
The p53 R181C mutation accumulates through impaired deacetylation by Sirt1 and facilitates tumor development.
Wang E et al.
Communications Biology, 2026
The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer.
Ju J et al.
The Journal of Clinical Investigation, 2024
Cooperative effects of SIRT1 and SIRT2 on APP acetylation.
Li N et al.
Aging Cell, 2023
Oncogenic KRAS mutation confers chemoresistance by upregulating SIRT1 in non-small cell lung cancer.
Shin DH et al.
Experimental & Molecular Medicine, 2023
SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex.
Rasti G et al.
Nucleic Acids Research, 2023
Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response.
Zhao R et al.
Cell Reports, 2023
SIRT1 deficiency increases O-GlcNAcylation of tau, mediating synaptic tauopathy.
Yin X et al.
Molecular Psychiatry, 2022
Dynamic switching of crotonylation to ubiquitination of H2A at lysine 119 attenuates transcription-replication conflicts caused by replication stress.
Hao S et al.
Nucleic Acids Research, 2022
Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ.
Zhou Q et al.
Nature Communications, 2022
Convergence of SIRT1 and ATR signaling to modulate replication origin dormancy.
Thakur BL et al.
Nucleic Acids Research, 2022
SIRT1 regulates cardiomyocyte alignment during maturation.
Fang Y et al.
Journal of Cell Science, 2022
Acetylation-dependent regulation of BRAF oncogenic function.
Dai X et al.
Cell Reports, 2022
LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity.
Yan P et al.
Cell Reports, 2021
Lysine acetyltransferase Tip60 acetylates the APP adaptor Fe65 to increase its transcriptional activity.
Probst S et al.
Biological Chemistry, 2021
Human SIRT1 Multispecificity Is Modulated by Active-Site Vicinity Substitutions during Natural Evolution.
Hendler A et al.
Molecular Biology and Evolution, 2021
NQO1 Binds and Supports SIRT1 Function.
Tsvetkov P et al.
Frontiers in Pharmacology, 2021
Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice.
Meng F et al.
Elife, 2020
FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku.
Jin H et al.
Nature Communications, 2020
Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation.
Wang J et al.
Nature Communications, 2020
SIRT1 modulates cell cycle progression by regulating CHK2 acetylation-phosphorylation.
Zhang W et al.
Cell Death and Differentiation, 2020
CCDC84 Acetylation Oscillation Regulates Centrosome Duplication by Modulating HsSAS-6 Degradation.
Wang T et al.
Cell Reports, 2019
Werner Helicase Control of Human Papillomavirus 16 E1-E2 DNA Replication Is Regulated by SIRT1 Deacetylation.
Das D et al.
Mbio, 2019
Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1.
Pfister JA et al.
Plos One, 2019
Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication.
Ling H et al.
Cell Reports, 2018
Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice.
Qian S et al.
Aging, 2018
SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function.
Sun J et al.
Cell Stem Cell, 2018
Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a.
Xin X et al.
Molecular Cancer, 2018
Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate.
Li TY et al.
Nature Communications, 2018
BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis.
Lahusen TJ et al.
Oncogene, 2018
Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3.
Kwon S et al.
The Journal of Biological Chemistry, 2017
Could Sirtuin Activities Modify ALS Onset and Progression?
Tang BL
Cellular and Molecular Neurobiology, 2017
SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation.
Sabir MS et al.
The Journal of Steroid Biochemistry and Molecular Biology, 2017
UV-Induced RPA1 Acetylation Promotes Nucleotide Excision Repair.
He H et al.
Cell Reports, 2017
Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel.
Vikram A et al.
Nature Medicine, 2017
Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity.
Pasquel D et al.
Biochimica Et Biophysica Acta, 2016
Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia.
Bao J et al.
Protein & Cell, 2016
Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues.
Xu C et al.
Diabetes, 2015
Ubiquitinated sirtuin 1 (SIRT1) function is modulated during DNA damage-induced cell death and survival.
Peng L et al.
The Journal of Biological Chemistry, 2015
Sirtuin 1 stabilization by HuR represses TNF-α- and glucose-induced E-selectin release and endothelial cell adhesiveness in vitro: relevance to human metabolic syndrome.
Ceolotto G et al.
Clinical Science (london, England : 1979), 2014
Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells.
Tian L et al.
Oncotarget, 2014
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
Armour SM et al.
Molecular and Cellular Biology, 2013
SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells.
Wang Z et al.
Oncogene, 2013
AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells.
Lee CW et al.
Cancer Research, 2012