Associated Papers
MRE11 deacetylation by SIRT2 promotes DNA binding to facilitate DNA end resection and ATM-dependent signaling.
Sesay F et al.
The Journal of Clinical Investigation, 2026
Lactate orchestrates the TGFβ pathway and ferroptosis nexus in organ fibrosis via USP2 lactylation.
Xiang J et al.
Communications Biology, 2025
Structural basis for sirtuin 2 activity and modulation: Current state and opportunities.
Bernhard SP et al.
The Journal of Biological Chemistry, 2025
SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress.
Karim R et al.
Elife, 2025
Mitochondrial SIRT2-mediated CPT2 deacetylation prevents diabetic cardiomyopathy by impeding cardiac fatty acid oxidation.
Guo Y et al.
International Journal of Biological Sciences, 2025
The role of NAD-dependent deacetylase sirtuin-2 in liver metabolic stress through regulating pyruvate kinase M2 ubiquitination.
Guo J et al.
Journal of Translational Medicine, 2024
SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner.
Geng A et al.
Nucleic Acids Research, 2024
Cooperative effects of SIRT1 and SIRT2 on APP acetylation.
Li N et al.
Aging Cell, 2023
Prdx5 regulates DNA damage response through autophagy-dependent Sirt2-p53 axis.
Agborbesong E et al.
Human Molecular Genetics, 2023
Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity.
Hu L et al.
Iscience, 2021
SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation.
Minten EV et al.
Cell Reports, 2021
Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer.
Liu HY et al.
Nucleic Acids Research, 2020
Nuclear E-Cadherin Acetylation Promotes Colorectal Tumorigenesis via Enhancing β-Catenin Activity.
Zhao Y et al.
Molecular Cancer Research : Mcr, 2019
SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation.
Sarikhani M et al.
Elife, 2018
SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a.
Jing H et al.
Elife, 2017
Sirtuin 2 mutations in human cancers impair its function in genome maintenance.
Head PE et al.
The Journal of Biological Chemistry, 2017
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
de Oliveira RM et al.
Plos Biology, 2017
The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer.
Zhou W et al.
Cell Reports, 2016
SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth.
Park SH et al.
Cancer Research, 2016
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.
Zhang H et al.
Cell Reports, 2016
Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity.
Park JM et al.
Scientific Reports, 2015
Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT2 down-regulates its enzymatic activity.
Tsusaka T et al.
Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2014
Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress.
Wang YP et al.
The Embo Journal, 2014
Modulation of p53 C-terminal acetylation by mdm2, p14ARF, and cytoplasmic SirT2.
van Leeuwen IM et al.
Molecular Cancer Therapeutics, 2013
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase.
Jiang W et al.
Molecular Cell, 2011
Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin.
Nahhas F et al.
Molecular and Cellular Biochemistry, 2007
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis.
North BJ et al.
Plos One, 2007
Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation.
North BJ et al.
The Journal of Biological Chemistry, 2007