Associated Papers
Mitochondrial reverse electron transport regulates glioma stemness through Sirt3-HIF1α-SOX2 signaling.
Khaket TP et al.
Cancer Letters, 2026
Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity.
Liu X et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy.
Li Z et al.
International Journal of Biological Sciences, 2024
Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice.
Garcia Castro DR et al.
Iscience, 2023
mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.
Liu R et al.
Nature Communications, 2021
TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin Toxicity.
Wang CY et al.
Biology, 2020
Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell.
Wan X et al.
Cell Death & Disease, 2020
Deacetylation of HSD17B10 by SIRT3 regulates cell growth and cell resistance under oxidative and starvation stresses.
Liu L et al.
Cell Death & Disease, 2020
SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism.
Chen S et al.
Neoplasia (new York, N.y.), 2019
Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis.
Li M et al.
Cancer Cell, 2019
Molecular basis for hierarchical histone de-β-hydroxybutyrylation by SIRT3.
Zhang X et al.
Cell Discovery, 2019
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.
Wei Z et al.
Nature Communications, 2018
Human sirtuin 3 (SIRT3) deacetylates histone H3 lysine 56 to promote nonhomologous end joining repair.
Sengupta A et al.
Dna Repair, 2018
Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3.
Kwon S et al.
The Journal of Biological Chemistry, 2017
Acetylation targets HSD17B4 for degradation via the CMA pathway in response to estrone.
Zhang Y et al.
Autophagy, 2017
Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.
Bharathi SS et al.
The Journal of Biological Chemistry, 2013
Role of SIRT3 in the regulation of redox balance during oral carcinogenesis.
Chen IC et al.
Molecular Cancer, 2013
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
Hirschey MD et al.
Molecular Cell, 2011
Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS.
Chen Y et al.
Embo Reports, 2011
Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity.
Finley LW et al.
Plos One, 2011
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.
Shimazu T et al.
Cell Metabolism, 2010
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy.
Hafner AV et al.
Aging, 2010
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
Hirschey MD et al.
Nature, 2010
Acetylation of mitochondrial proteins.
Hirschey MD et al.
Methods in Enzymology, 2009