Varaico: Literature-Extracted Genetic Variants

Gene:SIRT3
Variant:p.V208I
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SIRT3

NM_012239.6:p.V208I

Associated Papers

Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3.

Kwon S et al.

The Journal of Biological Chemistry, 2017

A systematic review of genetic mutations in pulmonary arterial hypertension.

Garcia-Rivas G et al.

Bmc Medical Genetics, 2017

28768485 (PubMed )
Supplement: 12881_2017_440_MOESM1_ESM.xlsx › table-mutations-per-gene

Genetic and Functional Sequence Variants of the SIRT3 Gene Promoter in Myocardial Infarction.

Yin X et al.

Plos One, 2016

Role of SIRT3 in the regulation of redox balance during oral carcinogenesis.

Chen IC et al.

Molecular Cancer, 2013

Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease.

Newman JC et al.

The Journal of Biological Chemistry, 2012

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.

Hirschey MD et al.

Molecular Cell, 2011

Mitochondrial SIRT3: a new potential therapeutic target for metabolic syndrome.

Yoshino J et al.

Molecular Cell, 2011

SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism.

Hirschey MD et al.

Cold Spring Harbor Symposia on Quantitative Biology, 2011

SIRT3 SNPs validation in 640 individuals, functional analyses and new insights into SIRT3 stability.

Dransfeld CL et al.

International Journal of Oncology, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."