Associated Papers
SIRT5-mediated desuccinylation of the porcine deltacoronavirus M protein drives pexophagy to enhance viral proliferation.
Li Z et al.
Plos Pathogens, 2025
SIRT5 mutants reveal the role of conserved asparagine and glutamine residues in the NAD+-binding pocket.
Yokoyama T et al.
Febs Letters, 2024
Mitochondrial glycerol 3-phosphate dehydrogenase deficiency exacerbates lipotoxic cardiomyopathy.
Qu H et al.
Iscience, 2024
Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice.
Yuan T et al.
Iscience, 2024
SIRT5 variants from patients with mitochondrial disease are associated with reduced SIRT5 stability and activity, but not with neuropathology.
Yuan T et al.
Biorxiv : the Preprint Server for Biology, 2023
Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage.
Liu X et al.
Cell Death and Differentiation, 2022
Demalonylation of DDX3 by Sirtuin 5 promotes antiviral innate immune responses.
He X et al.
Theranostics, 2021
SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress.
Zhang M et al.
Plos One, 2019
Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner.
Wang YQ et al.
Nature Communications, 2018
Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain.
Zhang Y et al.
The Journal of Biological Chemistry, 2017
STAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism.
Xu YS et al.
Scientific Reports, 2016
SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target.
Nishida Y et al.
Molecular Cell, 2015
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.
Tan M et al.
Cell Metabolism, 2014
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.
Rardin MJ et al.
Cell Metabolism, 2013
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.
Nakagawa T et al.
Cell, 2009
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