Varaico: Literature-Extracted Genetic Variants

Gene:SIRT6
Variant:p.D63H
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SIRT6

NM_016539.4:p.D63H

Associated Papers

Association of SIRT1 rs12415800 and SIRT6 rs350844 polymorphisms with preeclampsia: A case-control study.

Zhu C et al.

Pregnancy Hypertension, 2025

The association of the SIRT6 rs117385980 variant with frailty and longevity: an exploratory study.

Sheikholmolouki E et al.

Scientific Reports, 2025

A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A.

Simon M et al.

The Embo Journal, 2022

Mechanism of activation for the sirtuin 6 protein deacylase.

Klein MA et al.

The Journal of Biological Chemistry, 2020

SIRT6 is a DNA double-strand break sensor.

Onn L et al.

Elife, 2020

Sirtuins in Alzheimer's Disease: SIRT2-Related GenoPhenotypes and Implications for PharmacoEpiGenetics.

Cacabelos R et al.

International Journal of Molecular Sciences, 2019

SIRT6 deficiency results in developmental retardation in cynomolgus monkeys.

Zhang W et al.

Nature, 2018

An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.

Ferrer CM et al.

Genes & Development, 2018

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."