Associated Papers
SIRT7-mediated NRF2 deacetylation promotes antioxidant response and protects against chemodrug-induced liver injury.
Yu T et al.
Cell Death & Disease, 2025
SIRT7 facilitates endometrial cancer progression by regulating PTEN stability in an estrogen-dependent manner.
Hu Z et al.
Nature Communications, 2025
Structural basis of SIRT7 nucleosome engagement and substrate specificity.
Moreno-Yruela C et al.
Nature Communications, 2025
Inhibition of SIRT7 promotes STAT1 activation and STAT1-dependent signaling in hepatocellular carcinoma.
Dong L et al.
Cellular Signalling, 2024
Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner.
Liao L et al.
Cell Research, 2023
SIRT7 Facilitates CENP-A Nucleosome Assembly and Suppresses Intestinal Tumorigenesis.
Liu X et al.
Iscience, 2020
SIRT7: an influence factor in healthy aging and the development of age-dependent myeloid stem-cell disorders.
Kaiser A et al.
Leukemia, 2020
SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability.
Yu M et al.
International Journal of Molecular Sciences, 2020
SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle.
Lu YF et al.
Oncogene, 2020
SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway.
Zhao J et al.
Journal of Experimental & Clinical Cancer Research : Cr, 2019
SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair.
Tang M et al.
Science Advances, 2019
A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7.
Wang WW et al.
Journal of the American Chemical Society, 2019
Sirtuin 7-mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity.
Qi H et al.
The Journal of Biological Chemistry, 2018
The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability.
Paredes S et al.
The Journal of Biological Chemistry, 2018
Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.
Jiang L et al.
The Journal of Biological Chemistry, 2017
SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription.
Blank MF et al.
Nucleic Acids Research, 2017
SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability.
Li L et al.
Nature Communications, 2016
SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors.
Malik S et al.
Scientific Reports, 2015
Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging.
Mohrin M et al.
Science (new York, N.y.), 2015
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.
Barber MF et al.
Nature, 2012