Varaico: Literature-Extracted Genetic Variants

Gene:SLC10A1
Variant:p.I223T
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SLC10A1

NM_003049.4:p.I223T

Associated Papers

Amino acid substitutions at rheostat positions in the Na+/taurocholate cotransporting polypeptide substrate channel have pleiotropic effects.

Swint-Kruse L et al.

Protein Science : a Publication of the Protein Society, 2025

Effect of donor GSTM3 rs7483 genetic variant on tacrolimus elimination in the early period after liver transplantation.

Zhang T et al.

Peerj, 2024

39465171 (PubMed )
Supplement: peerj-12-18360-s002.7z › drug-metabolizing_enzymes_and_transporter__DMET__microarray › markerlist.xlsx › markerlist.TXT

Oligomerization of the HBV/HDV functional receptor NTCP expressed in Sf9 insect cell.

Qin T et al.

Biochimica Et Biophysica Acta. General Subjects, 2022

Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation.

Tremmel R et al.

International Journal of Molecular Sciences, 2022

35806468 (PubMed )
Supplement: ijms-23-07468-s001.zip › ijms-1789068-supplementary.pdf

Structural Plasticity Is a Feature of Rheostat Positions in the Human Na+/Taurocholate Cotransporting Polypeptide (NTCP).

Ruggiero MJ et al.

International Journal of Molecular Sciences, 2022

NTCP Deficiency Affects the Levels of Circulating Bile Acids and Induces Osteoporosis.

Yang F et al.

Frontiers in Endocrinology, 2022

Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia.

Wagner JB et al.

Clinical and Translational Science, 2020

Diverse Effects of the NTCP p.Ser267Phe Variant on Disease Progression During Chronic HBV Infection and on HBV preS1 Variability.

Yang F et al.

Frontiers in Cellular and Infection Microbiology, 2019

30881922 (PubMed )
Supplement: Table_1.docx

Analysis of hepatitis B virus preS1 variability and prevalence of the rs2296651 polymorphism in a Spanish population.

Casillas R et al.

World Journal of Gastroenterology, 2018

Monozygotic Twins Suffering From Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Case Report.

Tan HJ et al.

Frontiers in Pediatrics, 2018

Effect of S267F variant of NTCP on the patients with chronic hepatitis B.

Lee HW et al.

Scientific Reports, 2017

A genetic variant of the NTCP gene is associated with HBV infection status in a Chinese population.

Yang J et al.

Bmc Cancer, 2016

The p.Ser267Phe variant in SLC10A1 is associated with resistance to chronic hepatitis B.

Peng L et al.

Hepatology (baltimore, Md.), 2015

Deleterious nonsynonymous single nucleotide polymorphisms in human solute carriers: the first comparison of three prediction methods.

Hao DC et al.

European Journal of Drug Metabolism and Pharmacokinetics, 2013

Genetic polymorphisms in Na+-taurocholate co-transporting polypeptide (NTCP) and ileal apical sodium-dependent bile acid transporter (ASBT) and ethnic comparisons of functional variants of NTCP among Asian populations.

Pan W et al.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2011

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

Ho RH et al.

Gastroenterology, 2006

Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition.

Ho RH et al.

The Journal of Biological Chemistry, 2004

The solute carrier family 10 (SLC10): beyond bile acid transport.

Claro da Silva T et al.

Molecular Aspects of Medicine, 0

A clinically relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position.

Ruggiero MJ et al.

The Journal of Biological Chemistry, 0

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