Varaico: Literature-Extracted Genetic Variants

Gene:SLC10A1
Variant:p.A64T
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SLC10A1

NM_003049.4:p.A64T

Associated Papers

Amino acid substitutions at rheostat positions in the Na+/taurocholate cotransporting polypeptide substrate channel have pleiotropic effects.

Swint-Kruse L et al.

Protein Science : a Publication of the Protein Society, 2025

Molecular mechanisms of Na+-driven bile acid transport in human NTCP.

Lu X et al.

Biophysical Journal, 2024

When the same treatment has different response: The role of pharmacogenomics in statin therapy.

Zheng E et al.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2024

Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation.

Tremmel R et al.

International Journal of Molecular Sciences, 2022

35806468 (PubMed )
Supplement: ijms-23-07468-s001.zip › ijms-1789068-supplementary.pdf

Structural basis of sodium-dependent bile salt uptake into the liver.

Goutam K et al.

Nature, 2022

NTCP Deficiency Affects the Levels of Circulating Bile Acids and Induces Osteoporosis.

Yang F et al.

Frontiers in Endocrinology, 2022

In Vitro Functional Characterization and in Silico Prediction of Rare Genetic Variation in the Bile Acid and Drug Transporter, Na+-Taurocholate Cotransporting Polypeptide (NTCP, SLC10A1).

Russell LE et al.

Molecular Pharmaceutics, 2020

Diverse Effects of the NTCP p.Ser267Phe Variant on Disease Progression During Chronic HBV Infection and on HBV preS1 Variability.

Yang F et al.

Frontiers in Cellular and Infection Microbiology, 2019

30881922 (PubMed )
Supplement: Table_1.docx

Food Effect on Rosuvastatin Disposition and Low-Density Lipoprotein Cholesterol.

McLean CC et al.

Clinical Pharmacology and Therapeutics, 2018

Monozygotic Twins Suffering From Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Case Report.

Tan HJ et al.

Frontiers in Pediatrics, 2018

Mixed effects of OATP1B1, BCRP and NTCP polymorphisms on the population pharmacokinetics of pravastatin in healthy volunteers.

Lu XF et al.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2016

Viral entry of hepatitis B and D viruses and bile salts transportation share common molecular determinants on sodium taurocholate cotransporting polypeptide.

Yan H et al.

Journal of Virology, 2014

Genetic polymorphisms in Na+-taurocholate co-transporting polypeptide (NTCP) and ileal apical sodium-dependent bile acid transporter (ASBT) and ethnic comparisons of functional variants of NTCP among Asian populations.

Pan W et al.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2011

The solute carrier family 10 (SLC10): beyond bile acid transport.

Claro da Silva T et al.

Molecular Aspects of Medicine, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."