Associated Papers
Development of KCC2 therapeutics to treat neurological disorders.
Kadam SD et al.
Frontiers in Molecular Neuroscience, 2024
Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library.
Uvarov P et al.
Frontiers in Molecular Neuroscience, 2024
Excitatory/inhibitory balance in epilepsies and neurodevelopmental disorders: Depolarizing γ-aminobutyric acid as a common mechanism.
van van Hugte EJH et al.
Epilepsia, 2023
Targeting ischemia-induced KCC2 hypofunction rescues refractory neonatal seizures and mitigates epileptogenesis in a mouse model.
Sullivan BJ et al.
Science Signaling, 2021
Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters.
Murillo-de-Ozores AR et al.
Frontiers in Physiology, 2020
Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology.
Pisella LI et al.
Science Signaling, 2019
Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival.
Watanabe M et al.
Science Signaling, 2019
Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function.
Moore YE et al.
Frontiers in Molecular Neuroscience, 2019
Identification of KCC2 Mutations in Human Epilepsy Suggests Strategies for Therapeutic Transporter Modulation.
Duy PQ et al.
Frontiers in Cellular Neuroscience, 2019
A novel regulatory locus of phosphorylation in the C terminus of the potassium chloride cotransporter KCC2 that interferes with N-ethylmaleimide or staurosporine-mediated activation.
Weber M et al.
The Journal of Biological Chemistry, 2014
Taurine inhibits K+-Cl- cotransporter KCC2 to regulate embryonic Cl- homeostasis via with-no-lysine (WNK) protein kinase signaling pathway.
Inoue K et al.
The Journal of Biological Chemistry, 2012
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