Associated Papers
KCC2 activation during postnatal development alleviates long-term deficits in CDKL5-deficient mice.
Arshad MN et al.
Experimental & Molecular Medicine, 2026
The brain-specific kinase LMTK3 regulates neuronal excitability by decreasing KCC2-dependent neuronal Cl- extrusion.
Cho N et al.
Iscience, 2024
Excitatory/inhibitory balance in epilepsies and neurodevelopmental disorders: Depolarizing γ-aminobutyric acid as a common mechanism.
van van Hugte EJH et al.
Epilepsia, 2023
K+/Cl- cotransporter 2 (KCC2) and Na+/HCO3- cotransporter 1 (NBCe1) interaction modulates profile of KCC2 phosphorylation.
Pethe A et al.
Frontiers in Cellular Neuroscience, 2023
SNAP23 regulates KCC2 membrane insertion and activity following mZnR/GPR39 activation in hippocampalneurons.
Asraf H et al.
Iscience, 2022
Targeting ischemia-induced KCC2 hypofunction rescues refractory neonatal seizures and mitigates epileptogenesis in a mouse model.
Sullivan BJ et al.
Science Signaling, 2021
Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters.
Murillo-de-Ozores AR et al.
Frontiers in Physiology, 2020
Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology.
Pisella LI et al.
Science Signaling, 2019
Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival.
Watanabe M et al.
Science Signaling, 2019
Crossing the Chloride Channel: The Current and Potential Therapeutic Value of the Neuronal K+-Cl- Cotransporter KCC2.
Tillman L et al.
Biomed Research International, 2019
Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function.
Moore YE et al.
Frontiers in Molecular Neuroscience, 2019
Seizing Control of KCC2: A New Therapeutic Target for Epilepsy.
Moore YE et al.
Trends in Neurosciences, 2017
The KCC2 Cotransporter and Human Epilepsy: Getting Excited About Inhibition.
Kahle KT et al.
The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry, 2016
Compromising KCC2 transporter activity enhances the development of continuous seizure activity.
Kelley MR et al.
Neuropharmacology, 2016
KCC2 activity is critical in limiting the onset and severity of status epilepticus.
Silayeva L et al.
Proceedings of the National Academy of Sciences of the United States of America, 2015
Identification of key functional domains in the C terminus of the K+-Cl- cotransporters.
Bergeron MJ et al.
The Journal of Biological Chemistry, 2006