Associated Papers
Methotrexate recognition by the human reduced folate carrier SLC19A1.
Wright NJ et al.
Nature, 2022
Functional analysis of altered reduced folate carrier sequence changes identified in osteosarcomas.
Flintoff WF et al.
Biochimica Et Biophysica Acta, 2004
Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia.
Kaufman Y et al.
Cancer, 2004
Residues 45 and 404 in the murine reduced folate carrier may interact to alter carrier binding and mobility.
Zhao R et al.
Biochimica Et Biophysica Acta, 2003
Reduced folate carrier: biochemistry and molecular biology of the normal and methotrexate-resistant cell.
Bosson G
British Journal of Biomedical Science, 2003
Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells.
Gifford AJ et al.
Leukemia, 2002
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.
Jansen G et al.
The Journal of Biological Chemistry, 1998
A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.
Zhao R et al.
The Journal of Biological Chemistry, 1998
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