Varaico: Literature-Extracted Genetic Variants

Gene:SLC22A1
Variant:p.F161L
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SLC22A1

NM_003057.3:p.F161L

Associated Papers

Role of a Hydrophobic Pocket in Polyamine Interactions with the Polyspecific Organic Cation Transporter OCT3.

Li DC et al.

The Journal of Biological Chemistry, 2015

Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1.

Seitz T et al.

Genome Medicine, 2015

26157489 (PubMed )
Supplement: 13073_2015_172_MOESM6_ESM.docx

A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1.

Egenberger B et al.

The Journal of Biological Chemistry, 2012

High-affinity cation binding to organic cation transporter 1 induces movement of helix 11 and blocks transport after mutations in a modeled interaction domain between two helices.

Gorbunov D et al.

Molecular Pharmacology, 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."