Associated Papers
Complete loss of SLC30A8 in humans improves glucose metabolism and beta cell function.
Lamarche LB et al.
Diabetologia, 2025
The role of protective genetic variants in modulating epigenetic aging.
Bejaoui Y et al.
Geroscience, 2025
Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β-cell survival and function.
Hu M et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2024
Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β-cell survival and function.
Hu M et al.
Biorxiv : the Preprint Server for Biology, 2023
ZnT8 Loss of Function Mutation Increases Resistance of Human Embryonic Stem Cell-Derived Beta Cells to Apoptosis in Low Zinc Condition.
Sui L et al.
Cells, 2023
Impact of an SLC30A8 loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice.
Firth G et al.
Frontiers in Endocrinology, 2023
Toward Precision Medicine with Human Pluripotent Stem Cells for Diabetes.
Memon B et al.
Stem Cells Translational Medicine, 2022
Engineered pegRNAs improve prime editing efficiency.
Nelson JW et al.
Nature Biotechnology, 2022
Stem Cell-Derived β Cells: A Versatile Research Platform to Interrogate the Genetic Basis of β Cell Dysfunction.
Bartolomé A
International Journal of Molecular Sciences, 2022
Pancreatic β cell-selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis.
Xu J et al.
Jci Insight, 2021
Potential positive and negative consequences of ZnT8 inhibition.
Syring KE et al.
The Journal of Endocrinology, 2020
Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics.
Krentz NAJ et al.
Nature Reviews. Endocrinology, 2020
Structure/Function Analysis of human ZnT8 (SLC30A8): A Diabetes Risk Factor and Zinc Transporter.
Daniels MJ et al.
Current Research in Structural Biology, 2020
ZnT8 Haploinsufficiency Impacts MIN6 Cell Zinc Content and β-Cell Phenotype via ZIP-ZnT8 Coregulation.
Lawson R et al.
International Journal of Molecular Sciences, 2019
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.
Dwivedi OP et al.
Nature Genetics, 2019
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Flannick J et al.
Nature, 2019
Targeting the Zinc Transporter ZIP7 in the Treatment of Insulin Resistance and Type 2 Diabetes.
Adulcikas J et al.
Nutrients, 2019
Genetic, Functional, and Immunological Study of ZnT8 in Diabetes.
Huang Q et al.
International Journal of Endocrinology, 2019
Association analysis of copy number variations in type 2 diabetes-related susceptible genes in a Chinese population.
Yan YX et al.
Acta Diabetologica, 2018
Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity.
Kleiner S et al.
Proceedings of the National Academy of Sciences of the United States of America, 2018
High-Throughput Approaches onto Uncover (Epi)Genomic Architecture of Type 2 Diabetes.
Dziewulska A et al.
Genes, 2018
The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases.
Laakso M et al.
Journal of Lipid Research, 2017
Genetics of Type 2 Diabetes: the Power of Isolated Populations.
Andersen MK et al.
Current Diabetes Reports, 2016
Protective alleles and modifier variants in human health and disease.
Harper AR et al.
Nature Reviews. Genetics, 2015
Genetics of type 2 diabetes-pitfalls and possibilities.
Prasad RB et al.
Genes, 2015
Protein truncating variants of SLC30A8 reduce type 2 diabetes mellitus risk in humans.
Yakala GK
Clinical Genetics, 2014
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.
Flannick J et al.
Nature Genetics, 2014