Associated Papers
Experimental Models of Hypertrophic Cardiomyopathy: A Systematic Review.
van den Dolder FW et al.
Jacc. Basic to Translational Science, 2025
The Utility of Nuclear Imaging in Hypertrophic Cardiomyopathy: A Narrative Review.
Pradeep Kundur S et al.
Journal of Clinical Medicine, 2025
Computational and biophysical determination of pathogenicity of variants of unknown significance in cardiac thin filament.
Mason AB et al.
Jci Insight, 2021
Cardiomyopathy-associated mutations in tropomyosin differently affect actin-myosin interaction at single-molecule and ensemble levels.
Kopylova GV et al.
Journal of Muscle Research and Cell Motility, 2019
Genetic basis and outcome in a nationwide study of Finnish patients with hypertrophic cardiomyopathy.
Jääskeläinen P et al.
Esc Heart Failure, 2019
Functional significance of HCM mutants of tropomyosin, V95A and D175N, studied with in vitro motility assays.
Ishii S et al.
Biophysics and Physicobiology, 2019
Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy.
Ojala M et al.
Stem Cells International, 2016
A study of tropomyosin's role in cardiac function and disease using thin-filament reconstituted myocardium.
Bai F et al.
Journal of Muscle Research and Cell Motility, 2013
Alpha-tropomyosin mutations in inherited cardiomyopathies.
Redwood C et al.
Journal of Muscle Research and Cell Motility, 2013
Prevalence and distribution of sarcomeric gene mutations in Japanese patients with familial hypertrophic cardiomyopathy.
Otsuka H et al.
Circulation Journal : Official Journal of the Japanese Circulation Society, 2012
Enhanced active cross-bridges during diastole: molecular pathogenesis of tropomyosin's HCM mutations.
Bai F et al.
Biophysical Journal, 2011
Role of animal models in HCM research.
Shephard R et al.
Journal of Cardiovascular Translational Research, 2009
Cardiac dysfunction in hypertrophic cardiomyopathy mutant tropomyosin mice is transgene-dependent, hypertrophy-independent, and improved by beta-blockade.
Michele DE et al.
Circulation Research, 2002
Invited Review: pathophysiology of cardiac muscle contraction and relaxation as a result of alterations in thin filament regulation.
Hernandez OM et al.
Journal of Applied Physiology (bethesda, Md. : 1985), 2001
Animal models of hypertrophic cardiomyopathy.
Maass A et al.
Current Opinion in Cardiology, 2000
Regulation of contraction in striated muscle.
Gordon AM et al.
Physiological Reviews, 2000
Direct, convergent hypersensitivity of calcium-activated force generation produced by hypertrophic cardiomyopathy mutant alpha-tropomyosins in adult cardiac myocytes.
Michele DE et al.
Nature Medicine, 1999
Properties of mutant contractile proteins that cause hypertrophic cardiomyopathy.
Redwood CS et al.
Cardiovascular Research, 1999
Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy.
Watkins H et al.
The New England Journal of Medicine, 1995