Associated Papers
Functional role of serine 318 of the proton-coupled folate transporter in methotrexate transport.
Narawa T et al.
Drug Metabolism and Pharmacokinetics, 2021
The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption.
Zhao R et al.
Molecular Aspects of Medicine, 2017
Substituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter.
Wilson MR et al.
The Journal of Biological Chemistry, 2014
The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.
Matherly LH et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2014
The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.
Desmoulin SK et al.
Cancer Biology & Therapy, 2012
Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1).
Zhao R et al.
American Journal of Physiology. Cell Physiology, 2012
Identification and functional impact of homo-oligomers of the human proton-coupled folate transporter.
Hou Z et al.
The Journal of Biological Chemistry, 2012
Prevalence of a loss-of-function mutation in the proton-coupled folate transporter gene (PCFT-SLC46A1) causing hereditary folate malabsorption in Puerto Rico.
Mahadeo KM et al.
The Journal of Pediatrics, 2011
Random mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of function.
Zhao R et al.
The Journal of Biological Chemistry, 2011
Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption.
Shin DS et al.
Molecular Genetics and Metabolism, 2011
Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.
Shin DS et al.
Blood, 2010
Mutation of the proton-coupled folate transporter gene (PCFT-SLC46A1) in Turkish siblings with hereditary folate malabsorption.
Atabay B et al.
Pediatric Hematology and Oncology, 2010
A novel PCFT gene mutation (p.Cys66LeufsX99) causing hereditary folate malabsorption.
Meyer E et al.
Molecular Genetics and Metabolism, 2010
Hereditary folate malabsorption: a positively charged amino acid at position 113 of the proton-coupled folate transporter (PCFT/SLC46A1) is required for folic acid binding.
Lasry I et al.
Biochemical and Biophysical Research Communications, 2009
A novel loss-of-function mutation in the proton-coupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for function.
Lasry I et al.
Blood, 2008