Varaico: Literature-Extracted Genetic Variants

Gene:SLC6A4
Variant:p.K605N
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SLC6A4

NM_001045.6:p.K605N

Associated Papers

Modulation of Autism-Associated Serotonin Transporters by Palmitoylation: Insights into the Molecular Pathogenesis and Targeted Therapies for Autism Spectrum Disorder.

Brown CR et al.

Acs Chemical Neuroscience, 2025

The pharmacogenomic landscape in the Chinese: An analytics of pharmacogenetic variants in 206,640 individuals.

Wang LY et al.

Innovation (cambridge (mass.)), 2025

39991480 (PubMed )
Supplement: mmc5.xlsx › Sheet1

Functional and pathological consequences of being fast on the uptake: Protein kinase G and p38α MAPK regulation of serotonin transporters.

Gajeswski-Kurdziel PA et al.

Current Research in Physiology, 2024

Exploring the Structural and Functional Effects of Nonsynonymous SNPs in the Human Serotonin Transporter Gene Through In Silico Approaches.

Mia MA et al.

Bioinformatics and Biology Insights, 2022

Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits.

Bhat S et al.

Pharmacology & Therapeutics, 2021

Rare Opportunities for Insights Into Serotonergic Contributions to Brain and Bowel Disorders: Studies of the SERT Ala56 Mouse.

Stilley SE et al.

Frontiers in Cellular Neuroscience, 2021

Human Serotonin Transporter Coding Variation Establishes Conformational Bias with Functional Consequences.

Quinlan MA et al.

Acs Chemical Neuroscience, 2019

Resequencing three candidate genes discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese.

Rao S et al.

Gene, 2017

Rare Variants of the Serotonin Transporter Are Associated With Psychiatric Comorbidity in Irritable Bowel Syndrome.

Kohen R et al.

Biological Research for Nursing, 2016

X-ray structures and mechanism of the human serotonin transporter.

Coleman JA et al.

Nature, 2016

Association and interaction analyses of 5-HT3 receptor and serotonin transporter genes with alcohol, cocaine, and nicotine dependence using the SAGE data.

Yang J et al.

Human Genetics, 2014

Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transporters.

Chiba P et al.

Pharmacological Research, 2014

Independent effects of 5' and 3' functional variants in the serotonin transporter gene on suicidal behavior in the context of childhood trauma.

Enoch MA et al.

Journal of Psychiatric Research, 2013

Natural and engineered coding variation in antidepressant-sensitive serotonin transporters.

Ye R et al.

Neuroscience, 2011

Regulation of monoamine transporters: Role of transporter phosphorylation.

Ramamoorthy S et al.

Pharmacology & Therapeutics, 2011

An international multicenter association study of the serotonin transporter gene in persistent ADHD.

Landaas ET et al.

Genes, Brain, and Behavior, 2010

An improved in silico selection of phenotype affecting polymorphisms in SLC6A4, HTR1A and HTR2A genes.

Piva F et al.

Human Psychopharmacology, 2010

Detailed analysis of the serotonin transporter gene (SLC6A4) shows no association with bipolar disorder in the Northern Swedish population.

Alaerts M et al.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 2009

Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse.

Veenstra-Vanderweele J et al.

Journal of Neurodevelopmental Disorders, 2009

SLC6A4 variation and citalopram response.

Mrazek DA et al.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 2009

Characterization of a functional polymorphism in the 3' UTR of SLC6A4 and its association with drinking intensity.

Seneviratne C et al.

Alcoholism, Clinical and Experimental Research, 2009

Enhanced activity of human serotonin transporter variants associated with autism.

Prasad HC et al.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 2009

A large-scale screen for coding variants in SERT/SLC6A4 in autism spectrum disorders.

Sakurai T et al.

Autism Research : Official Journal of the International Society for Autism Research, 2008

Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP.

Ramamoorthy S et al.

The Journal of Biological Chemistry, 2007

Analysis of SNP profiles in patients with major depressive disorder.

Kõks S et al.

The International Journal of Neuropsychopharmacology, 2006

Human genetics and pharmacology of neurotransmitter transporters.

Lin Z et al.

Handbook of Experimental Pharmacology, 2006

Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase.

Prasad HC et al.

Proceedings of the National Academy of Sciences of the United States of America, 2005

Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors.

Sutcliffe JS et al.

American Journal of Human Genetics, 2005

Association between polymorphisms in the human serotonin transporter gene and lifelong premature ejaculation in the Han population.

Peng DW et al.

Asian Journal of Andrology, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."