Associated Papers
Thermal Unfolding of the Human Serotonin Transporter: Differential Effect by Stabilizing and Destabilizing Mutations and Cholesterol on Thermodynamic and Kinetic Stability.
Ponleitner M et al.
Molecular Pharmacology, 2022
Serotonin Transporter Ala276 Mouse: Novel Model to Assess the Neurochemical and Behavioral Impact of Thr276 Phosphorylation In Vivo.
Meinke C et al.
Neurochemical Research, 2022
Illumination of serotonin transporter mechanism and role of the allosteric site.
Yang D et al.
Science Advances, 2021
The Structure and Mechanism of Drug Transporters.
Roberts AG
Methods in Molecular Biology (clifton, N.j.), 2021
Chemical and structural investigation of the paroxetine-human serotonin transporter complex.
Coleman JA et al.
Elife, 2020
Computation-guided analysis of paroxetine binding to hSERT reveals functionally important structural elements and dynamics.
Abramyan AM et al.
Neuropharmacology, 2019
A Novel Bromine-Containing Paroxetine Analogue Provides Mechanistic Clues for Binding Ambiguity at the Central Primary Binding Site of the Serotonin Transporter.
Slack RD et al.
Acs Chemical Neuroscience, 2019
Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Coleman JA et al.
Nature, 2019
Insights into the mechanism and pharmacology of neurotransmitter sodium symporters.
Navratna V et al.
Current Opinion in Structural Biology, 2019
Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site.
Wahlgren WY et al.
Nature Communications, 2018
Structural basis for recognition of diverse antidepressants by the human serotonin transporter.
Coleman JA et al.
Nature Structural & Molecular Biology, 2018
A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition.
Zeppelin T et al.
Plos Computational Biology, 2018
Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram.
Coleman JA et al.
Journal of Visualized Experiments : Jove, 2016
Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands.
Andersen J et al.
Acs Chemical Neuroscience, 2016
X-ray structures and mechanism of the human serotonin transporter.
Coleman JA et al.
Nature, 2016
Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation.
Green EM et al.
Plos One, 2015
Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.
Andersen J et al.
The Journal of Biological Chemistry, 2010