Varaico: Literature-Extracted Genetic Variants

Gene:SLC6A4
Variant:p.I425V
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SLC6A4

NM_001045.6:p.I425V

Associated Papers

DNA Sequence Variations Affecting Serotonin Transporter Transcriptional Regulation and Activity: Do They Impact Alcohol Addiction?

Ferraguti G et al.

International Journal of Molecular Sciences, 2024

Pharmacogenetics of selective serotonin reuptake inhibitors (SSRI): A serotonin reuptake transporter (SERT)-based approach.

Sreeja V et al.

Neurochemistry International, 2024

Disruptive mutations in the serotonin transporter associate serotonin dysfunction with treatment-resistant affective disorder.

Støier JF et al.

Medrxiv : the Preprint Server for Health Sciences, 2023

Interplay between Serotonin, Immune Response, and Intestinal Dysbiosis in Inflammatory Bowel Disease.

González Delgado S et al.

International Journal of Molecular Sciences, 2022

Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder.

Gupta R et al.

Neurotoxicity Research, 2022

Sudden infant death syndrome revisited: serotonin transporter gene, polymorphisms and promoter methylation.

Pfisterer N et al.

Pediatric Research, 2022

Current understanding of the genetics of tourette syndrome.

Lin WD et al.

Biomedical Journal, 2022

Serotonin Transporter Ala276 Mouse: Novel Model to Assess the Neurochemical and Behavioral Impact of Thr276 Phosphorylation In Vivo.

Meinke C et al.

Neurochemical Research, 2022

Exploring the Structural and Functional Effects of Nonsynonymous SNPs in the Human Serotonin Transporter Gene Through In Silico Approaches.

Mia MA et al.

Bioinformatics and Biology Insights, 2022

Candidate Genes and Pathways Associated with Gilles de la Tourette Syndrome-Where Are We?

Levy AM et al.

Genes, 2021

Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits.

Bhat S et al.

Pharmacology & Therapeutics, 2021

Association between temperament related traits and single nucleotide polymorphisms in the serotonin and oxytocin systems in Merino sheep.

Ding L et al.

Genes, Brain, and Behavior, 2021

Elevated Expression of SLC6A4 Encoding the Serotonin Transporter (SERT) in Gilles de la Tourette Syndrome.

Hildonen M et al.

Genes, 2021

Rare Opportunities for Insights Into Serotonergic Contributions to Brain and Bowel Disorders: Studies of the SERT Ala56 Mouse.

Stilley SE et al.

Frontiers in Cellular Neuroscience, 2021

Sequence analysis of five exons of SLC6A4 gene in Mexican patients with anorexia nervosa and bulimia nervosa.

Hernández-Muñoz S et al.

Gene, 2020

Analysis of the Prader-Willi syndrome imprinting center using droplet digital PCR and next-generation whole-exome sequencing.

Hartin SN et al.

Molecular Genetics & Genomic Medicine, 2019

Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response.

Baudry A et al.

Frontiers in Neuroscience, 2019

Identification of single nucleotide polymorphisms in carnosine-related genes and effects of genotypes on pork meat quality attributes.

D'Astous-Pagé J et al.

Meat Science, 2017

A review of the role of serotonin system genes in obsessive-compulsive disorder.

Sinopoli VM et al.

Neuroscience and Biobehavioral Reviews, 2017

Potentiating SLC transporter activity: Emerging drug discovery opportunities.

Rives ML et al.

Biochemical Pharmacology, 2017

The serotonin system in autism spectrum disorder: From biomarker to animal models.

Muller CL et al.

Neuroscience, 2016

Functional Evaluations of Genes Disrupted in Patients with Tourette's Disorder.

Sun N et al.

Frontiers in Psychiatry, 2016

Pharmacogenetics of drug response in Parkinson's disease.

Džoljić E et al.

The International Journal of Neuroscience, 2015

Trio study and meta-analysis support the association of genetic variation at the serotonin transporter with early-onset obsessive-compulsive disorder.

Walitza S et al.

Neuroscience Letters, 2014

Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transporters.

Chiba P et al.

Pharmacological Research, 2014

The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction.

Rudnick G et al.

Pflugers Archiv : European Journal of Physiology, 2014

Rare coding variants of the adenosine A3 receptor are increased in autism: on the trail of the serotonin transporter regulome.

Campbell NG et al.

Molecular Autism, 2013

Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder.

Moya PR et al.

Movement Disorders : Official Journal of the Movement Disorder Society, 2013

Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity.

Murphy DL et al.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 2013

Genetic susceptibility and neurotransmitters in Tourette syndrome.

Paschou P et al.

International Review of Neurobiology, 2013

The solute carrier 6 family of transporters.

Bröer S et al.

British Journal of Pharmacology, 2012

Networking in autism: leveraging genetic, biomarker and model system findings in the search for new treatments.

Veenstra-VanderWeele J et al.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 2012

Genetic polymorphism of serotonin transporter 5-HTTLPR: involvement in smoking behaviour.

Watanabe MA et al.

Journal of Genetics, 2011

Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G×G and G×E differences in health and disease.

Murphy DL et al.

Current Opinion in Pharmacology, 2011

Myristoylation of cGMP-dependent protein kinase dictates isoform specificity for serotonin transporter regulation.

Zhang YW et al.

The Journal of Biological Chemistry, 2011

Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study.

Voyiaziakis E et al.

Molecular Psychiatry, 2011

Association and gene-gene interaction of SLC6A4 and ITGB3 in autism.

Ma DQ et al.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 2010

Molecular genetics of attention deficit hyperactivity disorder.

Faraone SV et al.

The Psychiatric Clinics of North America, 2010

Accurate, Large-Scale Genotyping of 5HTTLPR and Flanking Single Nucleotide Polymorphisms in an Association Study of Depression, Anxiety, and Personality Measures.

Wray NR et al.

Biological Psychiatry, 2009

Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse.

Veenstra-Vanderweele J et al.

Journal of Neurodevelopmental Disorders, 2009

The genetics of obsessive-compulsive disorder and Tourette's syndrome: what are the common factors?

Grados MA

Current Psychiatry Reports, 2009

Enhanced activity of human serotonin transporter variants associated with autism.

Prasad HC et al.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 2009

Pharmacogenetics and the serotonin transporter in late-life depression.

Gerretsen P et al.

Expert Opinion on Drug Metabolism & Toxicology, 2008

Population-based association study and contrasting linkage disequilibrium pattern reveal genetic association of SLC6A4 with autism in the Indian population from West Bengal.

Guhathakurta S et al.

Brain Research, 2008

How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems.

Murphy DL et al.

Neuropharmacology, 2008

A large-scale screen for coding variants in SERT/SLC6A4 in autism spectrum disorders.

Sakurai T et al.

Autism Research : Official Journal of the International Society for Autism Research, 2008

Association study between obsessive-compulsive disorder and serotonergic candidate genes.

Saiz PA et al.

Progress in Neuro-psychopharmacology & Biological Psychiatry, 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."