Varaico: Literature-Extracted Genetic Variants

Gene:SLC6A4
Variant:p.D98E
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SLC6A4

NM_001045.6:p.D98E

Associated Papers

Free energy profile of the substrate-induced occlusion of the human serotonin transporter.

Alves da Silva L et al.

Journal of Neurochemistry, 2024

Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors.

Gradisch R et al.

Nature Communications, 2024

Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain.

Gradisch R et al.

The Journal of Biological Chemistry, 2022

Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation.

Rannversson H et al.

The Journal of Biological Chemistry, 2015

Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.

Andersen J et al.

The Journal of Biological Chemistry, 2010

Homology modeling of the serotonin transporter: insights into the primary escitalopram-binding site.

Jørgensen AM et al.

Chemmedchem, 2007

Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6.

Chen NH et al.

Pflugers Archiv : European Journal of Physiology, 2004

Glutamate 59 is critical for transport function of the amino acid cotransporter KAAT1.

Sacchi VF et al.

American Journal of Physiology. Cell Physiology, 2003

Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter.

Barker EL et al.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."