Varaico: Literature-Extracted Genetic Variants

Gene:SLC6A4
Variant:p.G56A
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SLC6A4

NM_001045.6:p.G56A

Associated Papers

Modulation of Autism-Associated Serotonin Transporters by Palmitoylation: Insights into the Molecular Pathogenesis and Targeted Therapies for Autism Spectrum Disorder.

Brown CR et al.

Acs Chemical Neuroscience, 2025

Modulation of autism-associated serotonin transporters by palmitoylation: Insights into the molecular pathogenesis and targeted therapies for autism spectrum disorder.

Brown CR et al.

Biorxiv : the Preprint Server for Biology, 2025

Insight into the Association between Slitrk Protein and Neurodevelopmental and Neuropsychiatric Conditions.

Puranik N et al.

Biomolecules, 2024

DNA Sequence Variations Affecting Serotonin Transporter Transcriptional Regulation and Activity: Do They Impact Alcohol Addiction?

Ferraguti G et al.

International Journal of Molecular Sciences, 2024

Functional and pathological consequences of being fast on the uptake: Protein kinase G and p38α MAPK regulation of serotonin transporters.

Gajeswski-Kurdziel PA et al.

Current Research in Physiology, 2024

Disruptive mutations in the serotonin transporter associate serotonin dysfunction with treatment-resistant affective disorder.

Støier JF et al.

Medrxiv : the Preprint Server for Health Sciences, 2023

Serotonin Transporter Ala276 Mouse: Novel Model to Assess the Neurochemical and Behavioral Impact of Thr276 Phosphorylation In Vivo.

Meinke C et al.

Neurochemical Research, 2022

Exploring the Structural and Functional Effects of Nonsynonymous SNPs in the Human Serotonin Transporter Gene Through In Silico Approaches.

Mia MA et al.

Bioinformatics and Biology Insights, 2022

A systematic review of common genetic variation and biological pathways in autism spectrum disorder.

Rodriguez-Gomez DA et al.

Bmc Neuroscience, 2021

Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits.

Bhat S et al.

Pharmacology & Therapeutics, 2021

Population genetic variation of SLC6A4 gene, associated with neurophysiological development.

Hande SH et al.

Journal of Genetics, 2021

Rare Opportunities for Insights Into Serotonergic Contributions to Brain and Bowel Disorders: Studies of the SERT Ala56 Mouse.

Stilley SE et al.

Frontiers in Cellular Neuroscience, 2021

microRNAs and Gene-Environment Interactions in Autism: Effects of Prenatal Maternal Stress and the SERT Gene on Maternal microRNA Expression.

Beversdorf DQ et al.

Frontiers in Psychiatry, 2021

A social encounter drives gene expression changes linked to neuronal function, brain development, and related disorders in mice expressing the serotonin transporter Ala56 variant.

O'Reilly KC et al.

Neuroscience Letters, 2020

Leveraging Human Genetics to Identify Safety Signals Prior to Drug Marketing Approval and Clinical Use.

Jerome RN et al.

Drug Safety, 2020

Colonic dilation and altered ex vivo gastrointestinal motility in the neuroligin-3 knockout mouse.

Leembruggen AJL et al.

Autism Research : Official Journal of the International Society for Autism Research, 2020

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

Quinlan MA et al.

Frontiers in Molecular Neuroscience, 2020

Oxidative Stress, Folate Receptor Autoimmunity, and CSF Findings in Severe Infantile Autism.

Ramaekers VT et al.

Autism Research and Treatment, 2020

Post-translational modifications of serotonin transporter.

Cooper A et al.

Pharmacological Research, 2019

Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response.

Baudry A et al.

Frontiers in Neuroscience, 2019

Analysis of neuroanatomical differences in mice with genetically modified serotonin transporters assessed by structural magnetic resonance imaging.

Ellegood J et al.

Molecular Autism, 2018

A review of the role of serotonin system genes in obsessive-compulsive disorder.

Sinopoli VM et al.

Neuroscience and Biobehavioral Reviews, 2017

Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment.

Muller CL et al.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 2017

Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function.

Margolis KG et al.

The Journal of Clinical Investigation, 2016

The serotonin system in autism spectrum disorder: From biomarker to animal models.

Muller CL et al.

Neuroscience, 2016

Targeted Re-Sequencing Approach of Candidate Genes Implicates Rare Potentially Functional Variants in Tourette Syndrome Etiology.

Alexander J et al.

Frontiers in Neuroscience, 2016

27708560 (PubMed )
Supplement: DataSheet1.xlsx › Table_S2

Analysis of SLITRK1 in Japanese patients with Tourette syndrome using a next-generation sequencer.

Inai A et al.

Psychiatric Genetics, 2015

Association study of the SLITRK5 gene and Tourette syndrome.

Zhang K et al.

Psychiatric Genetics, 2015

Pharmacogenetics of drug response in Parkinson's disease.

Džoljić E et al.

The International Journal of Neuroscience, 2015

XomAnnotate: Analysis of Heterogeneous and Complex Exome- A Step towards Translational Medicine.

Talukder AK et al.

Plos One, 2015

25905921 (PubMed )
Supplement: pone.0123569.s008.xls › BC9_ERR166333

Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transporters.

Chiba P et al.

Pharmacological Research, 2014

A G613A missense in the Hutchinson's progeria lamin A/C gene causes a lone, autosomal dominant atrioventricular block.

Villa F et al.

Immunity & Ageing : I & A, 2014

25469153 (PubMed )
Supplement: 12979_2014_19_MOESM2_ESM.xls › Sheet1

Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene.

Adamsen D et al.

Molecular Autism, 2014

Association between serotonin transporter gene polymorphisms and childhood asthma.

Farjadian S et al.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma, 2013

A review of the serotonin transporter and prenatal cortisol in the development of autism spectrum disorders.

Rose'meyer R

Molecular Autism, 2013

Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice.

Kerr TM et al.

Molecular Autism, 2013

Rare coding variants of the adenosine A3 receptor are increased in autism: on the trail of the serotonin transporter regulome.

Campbell NG et al.

Molecular Autism, 2013

Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder.

Moya PR et al.

Movement Disorders : Official Journal of the Movement Disorder Society, 2013

Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism.

Zuo L et al.

Human Genetics, 2013

Independent effects of 5' and 3' functional variants in the serotonin transporter gene on suicidal behavior in the context of childhood trauma.

Enoch MA et al.

Journal of Psychiatric Research, 2013

Sequence analysis of SLITRK1 for var321 in Danish patients with Tourette syndrome and review of the literature.

Yasmeen S et al.

Psychiatric Genetics, 2013

5HTTLPR: White Knight or Dark Blight?

Murphy DL et al.

Acs Chemical Neuroscience, 2013

Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity.

Murphy DL et al.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 2013

The serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: potential roles in genetic selection and gene × environment interactions.

Lindell SG et al.

Development and Psychopathology, 2012

5-HTTLPR polymorphism in bulimia nervosa: a multiple-model meta-analysis.

Polsinelli GN et al.

Psychiatric Genetics, 2012

SLC6A4 rare variant associated with eating disorders in Mexican patients.

Camarena B et al.

Journal of Psychiatric Research, 2012

Natural and engineered coding variation in antidepressant-sensitive serotonin transporters.

Ye R et al.

Neuroscience, 2011

Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders.

Robertson HR et al.

Journal of Child Psychology and Psychiatry, and Allied Disciplines, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."