Varaico: Literature-Extracted Genetic Variants

Gene:SLCO1A2
Variant:p.N128Y
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SLCO1A2

NM_001386879.1:p.N128Y

Associated Papers

Stoichiometric transport of estrone 3-sulfate among genetic variants of OATP1A2 and OATP2B1 and structural analysis by molecular dynamics simulation: Impairment of gating mechanism in the unstable inward-open conformation of OATP2B1 (Asp215Val) significantly suppress the transport activity.

Akiyoshi T et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2025

Impact of genetic variants in the solute carrier (SLC) genes encoding drug uptake transporters on the response to anticancer chemotherapy.

Marin JJG et al.

Cancer Drug Resistance (alhambra, Calif.), 2024

Effect of donor GSTM3 rs7483 genetic variant on tacrolimus elimination in the early period after liver transplantation.

Zhang T et al.

Peerj, 2024

39465171 (PubMed )
Supplement: peerj-12-18360-s002.7z › drug-metabolizing_enzymes_and_transporter__DMET__microarray › markerlist.xlsx › markerlist.TXT

Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants.

Han H et al.

Drug Metabolism and Pharmacokinetics, 2022

Comparison of the inhibitory properties of the fruit component naringenin and its glycosides against OATP1A2 genetic variants.

Araki N et al.

Drug Metabolism and Pharmacokinetics, 2022

Genetic variability and population diversity of the human SLCO (OATP) transporter family.

Zhang B et al.

Pharmacological Research, 2019

The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries.

Costa ACC et al.

European Journal of Clinical Pharmacology, 2017

Recent advance in the pharmacogenomics of human Solute Carrier Transporters (SLCs) in drug disposition.

Zhou F et al.

Advanced Drug Delivery Reviews, 2017

Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.

Lee HH et al.

Molecular Pharmacology, 2017

Genetic polymorphisms and function of the organic anion-transporting polypeptide 1A2 and its clinical relevance in drug disposition.

Zhou Y et al.

Pharmacology, 2015

Environmental and genetic factors affecting transport of imatinib by OATP1A2.

Eechoute K et al.

Clinical Pharmacology and Therapeutics, 2011

Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants.

Badagnani I et al.

The Journal of Pharmacology and Experimental Therapeutics, 2006

Implications of genetic polymorphisms in drug transporters for pharmacotherapy.

Kerb R

Cancer Letters, 2006

Pharmacogenomics of human OATP transporters.

König J et al.

Naunyn-schmiedeberg's Archives of Pharmacology, 2006

Membrane transporter proteins: a challenge for CNS drug development.

Girardin F

Dialogues in Clinical Neuroscience, 2006

Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry.

Lee W et al.

The Journal of Biological Chemistry, 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."