Varaico: Literature-Extracted Genetic Variants

Gene:SLCO1B1
Variant:p.N130D
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SLCO1B1

NM_006446.5:p.N130D

Associated Papers

HLA DRB1*01 and *04 Predisposition to Rheumatoid Arthritis and Polymorphisms of the SLCO1B1, MTHFR and PNPLA3 Genes Are Not Associated with Fatty Liver and Hepatotoxicity.

Zekić T et al.

Journal of Clinical Medicine, 2026

Long-Read Sequencing Enhances Pharmacogenomic Profiling by Resolving Complex Haplotypes, Novel Star Alleles, and Structural Variants.

Samarasinghe SR et al.

Clinical Pharmacology and Therapeutics, 2026

Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age-Related Studies in Thai Adults and Cross-Population Comparisons.

Srimatimanon T et al.

Clinical and Translational Science, 2026

Association between SLCO1B1, apolipoprotein E and ABCG2 genes and lipid response to rosuvastatin: a meta-analysis.

Li J et al.

Pharmacogenetics and Genomics, 2026

Clinical Implementation of Pharmacogenomics and Drug-Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow-Up.

Tremmel R et al.

Clinical Pharmacology and Therapeutics, 2026

41074844 (PubMed )
Supplement: CPT-119-241-s005.pdf

Pharmacogenetic hSLCO1B1*14-Guided Dosing of Methotrexate in Transgenic Arthritic Mice Normalizes Exposure and Response.

Gooden F et al.

Clinical and Translational Science, 2026

Analysis of the association between SLCO1B1 gene polymorphisms and coronary heart disease risk in southern Han Chinese population and statin responses in the elderly.

Long Y et al.

Frontiers in Cardiovascular Medicine, 2026

The impact of single nucleotide polymorphisms on the absorption, distribution, metabolism, and excretion of dietary (poly)phenols: a critical systematic review.

Tosi N et al.

Food & Function, 2025

Leveraging Genome-wide Association Studies to Identify Pathogenic Variants for Breast Cancer Among Multiple Continents.

Admanegara PPS et al.

Anticancer Research, 2025

Impact of SLCO1B1 (rs2306283) polymorphism on personalized atorvastatin dosing in a genetically distinct South Asian cohort.

Farooq T et al.

Bmc Pharmacology & Toxicology, 2025

Influence of genetic polymorphisms on gefitinib pharmacokinetics and adverse drug reactions in non-small cell lung cancer patients.

Shenoy PV et al.

Cancer Metastasis Reviews, 2025

41199076 (PubMed )
Supplement: 10555_2025_10299_MOESM1_ESM.xlsx › Gene_and_SNP_details

Retrospective Evaluation of the Impact of SLCO1B1 Variation on Statin Effectiveness.

Ahmed Feldman M et al.

Journal of Personalized Medicine, 2025

Structural equation modelling of nucleotide polymorphisms and pharmacokinetics in direct oral anticoagulant use for stroke and embolism prevention in atrial fibrillation.

Pham TP et al.

European Journal of Pharmacology, 2025

Correlation of APOE, SLCO1B1 and LPA KIV-2 gene polymorphisms with coronary heart disease in the Teochew population.

Xu JX et al.

World Journal of Cardiology, 2025

Influence of pharmacokinetics-related gene polymorphisms on plasma levels of clozapine and its metabolites in Japanese patients with schizophrenia.

Kinoshita S et al.

Pcn Reports : Psychiatry and Clinical Neurosciences, 2025

Physiologically-based pharmacokinetic modeling of rosuvastatin in Chinese: Predicting the impact of SLCO1B1 and ABCG2 genetic variants and hepatic impairment on drug exposure.

Li L et al.

Journal of Pharmaceutical Sciences, 2025

Unveiling hidden risks: pharmacogenetic insights from a cross-sectional study of statin therapy in the Indian population.

Naushad SM et al.

Pharmacological Reports : Pr, 2025

Association of SLCO1B3 and SLCO1B1 Polymorphisms with Methotrexate Efficacy and Toxicity in Saudi Rheumatoid Arthritis Patients.

Magadmi R et al.

Pharmaceuticals (basel, Switzerland), 2025

Comparative analysis of the single-molecule transport kinetics of OATP1B1 genetic variants.

Tsujii K et al.

Journal of Pharmacological Sciences, 2025

Effects of SCT genetic polymorphisms on methotrexate concentrations and toxicities in Chinese children with acute lymphoblastic leukemia.

Li M et al.

Leukemia & Lymphoma, 2025

Identification of Genetic Variants Associated with Pravastatin and Pitavastatin Pharmacokinetics.

Mykkänen AJH et al.

Clinical Pharmacology and Therapeutics, 2025

Impacts of Pharmacokinetic Gene Polymorphisms on Steady-State Plasma Concentrations of Simvastatin in Thai Population.

Tipnoppanon S et al.

Clinical and Translational Science, 2025

Contrastive sequence signatures between the both sides of a recombination spot reveal an adaptation at PPARD locus from standing variation for pleiotropy since out-of-Africa dispersal.

Shou W et al.

Bmc Genomics, 2025

40307732 (PubMed )
Supplement: 12864_2025_11620_MOESM2_ESM.xlsx › TS5

Pharmacogenomic insights into atorvastatin and rosuvastatin adverse effects: a prospective observational study in the UAE's multiethnic population.

Alqasrawi MN et al.

Human Genomics, 2025

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between SLCO1B1 and statins and CYP2C9 and sulfonylureas.

Wolthuis DFGJ et al.

European Journal of Human Genetics : Ejhg, 2025

The Impact of Organic Anion-Transporting Polypeptide (OATP) Variants on the Side Effects of Direct-Acting Antivirals in Hepatitis C Patients.

Altintas Z et al.

Cureus, 2025

Association of SLCO1B1 genetic variants with neonatal hyperbilirubinemia: a consolidated analysis of 36 studies.

Talebi H et al.

Bmc Pediatrics, 2025

Physiologically based pharmacokinetic (PBPK) modeling of gliclazide for different genotypes of CYP2C9 and CYP2C19.

Park HJ et al.

Archives of Pharmacal Research, 2025

Development of a vitrified CRISPR/Cas12b-based assay for rapid genotyping of SLCO1B1 SNPs without DNA amplification.

Lu C et al.

Analytical Methods : Advancing Methods and Applications, 2025

The pharmacogenomic landscape in the Chinese: An analytics of pharmacogenetic variants in 206,640 individuals.

Wang LY et al.

Innovation (cambridge (mass.)), 2025

The Role of Candidate Polymorphisms in Drug Transporter Genes on High-Dose Methotrexate in the Consolidation Phase of the AIEOP-BFM ALL 2009 Protocol.

Braidotti S et al.

Clinical and Translational Science, 2025

39891427 (PubMed )
Supplement: CTS-18-e70136-s001.docx

Value of Pharmacogenetic Testing Assessed with Real-World Drug Utilization and Genotype Data.

Litonius K et al.

Clinical Pharmacology and Therapeutics, 2025

39365028 (PubMed )
Supplement: CPT-117-278-s001.pdf

Publication bias in pharmacogenetics of statin-associated muscle symptoms: A meta-epidemiological study.

Gougeon A et al.

Atherosclerosis, 2025

SLCO1B1 variants in a patient of African ancestry presenting with rosuvastatin-induced rhabdomyolysis: A case report.

Medwid S et al.

British Journal of Clinical Pharmacology, 2025

Impacts of polymorphisms in drug-metabolizing enzyme and transporter genes on irinotecan toxicity and efficacy in Thai colorectal cancer patients.

Akarapredee N et al.

Plos One, 2025

A Rapid and Scalable Multiplex PCR-Based Next-Generation Amplicon Sequencing Method for Familial Hypercholesterolemia Genetic Screening.

Imran M et al.

The Journal of Applied Laboratory Medicine, 2024

CYP2B6 and ABCB1 genotypes predict methadone plasma exposure among patients on maintenance therapy against opioid addictions in Tanzania.

Mugusi S et al.

British Journal of Clinical Pharmacology, 2024

Association Between ABCC2 -24C>T and Nab-Paclitaxel-induced Peripheral Neuropathy in Japanese Patients With Pancreatic Cancer.

Nakayama H et al.

Anticancer Research, 2024

The reduced function allele SLCO1B1 c.521T>C is of no practical relevance for the renal graft function over the first post-transplant year in patients treated with mycophenolic acid.

Nađ Škegro S et al.

Pharmacogenetics and Genomics, 2024

A Nanopore Sequencing-based Pharmacogenomic Panel to Personalize Tuberculosis Drug Dosing.

Verma R et al.

American Journal of Respiratory and Critical Care Medicine, 2024

Major Genetic Drivers of Statin Treatment Response in African Populations and Pharmacogenetics of Dyslipidemia Through a One Health Lens.

Lusiki Z et al.

Omics : a Journal of Integrative Biology, 2024

Genome-Wide Association Study of Atorvastatin Pharmacokinetics: Associations With SLCO1B1, UGT1A3, and LPP.

Mykkänen AJH et al.

Clinical Pharmacology and Therapeutics, 2024

A mutation in CCDC91, Homo sapiens coiled-coil domain containing 91 protein, cause autosomal-dominant acrokeratoelastoidosis.

Zhu Y et al.

European Journal of Human Genetics : Ejhg, 2024

38627542 (PubMed )
Supplement: 41431_2024_1573_MOESM3_ESM.xlsx › Sheet1

APF2: an improved ensemble method for pharmacogenomic variant effect prediction.

Zhou Y et al.

The Pharmacogenomics Journal, 2024

38802404 (PubMed )
Supplement: 41397_2024_338_MOESM1_ESM.xlsx › Sheet1

SLCO1B1 Exome Sequencing and Statin Treatment Response in 64,000 UK Biobank Patients.

Türkmen D et al.

International Journal of Molecular Sciences, 2024

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."