Associated Papers
RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stress.
Stanage TH et al.
Nature Cell Biology, 2026
SLFN11 counteracts the RFWD3-PRIMPOL DNA damage tolerance axis to restrain gapped DNA synthesis in response to replication stress.
Coleman KE et al.
Nature Communications, 2025
The crucial role of single-stranded DNA binding in enhancing sensitivity to DNA-damaging agents for Schlafen 11 and Schlafen 13.
Fujiwara K et al.
Iscience, 2023
Mechanistic understanding of human SLFN11.
Metzner FJ et al.
Nature Communications, 2022
36115853 (PubMed )
Supplement: 41467_2022_33123_MOESM2_ESM.pdf
Structural, molecular, and functional insights into Schlafen proteins.
Jo U et al.
Experimental & Molecular Medicine, 2022
SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.
Jo U et al.
Proceedings of the National Academy of Sciences of the United States of America, 2021
Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress.
Murai J et al.
Cell Reports, 2020
SLFN11 Blocks Stressed Replication Forks Independently of ATR.
Murai J et al.
Molecular Cell, 2018
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