Varaico: Literature-Extracted Genetic Variants

Gene:SMAD2
Variant:p.P445H
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SMAD2

NM_005901.6:p.P445H

Associated Papers

Alterations in the Smad pathway in human cancers.

Samanta D et al.

Frontiers in Bioscience (landmark Edition), 2012

Cooperation between GATA4 and TGF-beta signaling regulates intestinal epithelial gene expression.

Belaguli NS et al.

American Journal of Physiology. Gastrointestinal and Liver Physiology, 2007

A mechanism for mutational inactivation of the homeodomain protein TGIF in holoprosencephaly.

Ferrand N et al.

Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2007

Formation of a stable heterodimer between Smad2 and Smad4.

Wu JW et al.

The Journal of Biological Chemistry, 2001

Mechanism for mutational inactivation of the tumor suppressor Smad2.

Prunier C et al.

Molecular and Cellular Biology, 2001

Evidence that Smad2 is a tumor suppressor implicated in the control of cellular invasion.

Prunier C et al.

The Journal of Biological Chemistry, 1999

Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus.

Hoodless PA et al.

Developmental Biology, 1999

TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.

Hata A et al.

Molecular Medicine Today, 1998

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.

Eppert K et al.

Cell, 1996

Alterations in components of the TGF-beta superfamily signaling pathways in human cancer.

Levy L et al.

Cytokine & Growth Factor Reviews, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."