Associated Papers
Alterations in the Smad pathway in human cancers.
Samanta D et al.
Frontiers in Bioscience (landmark Edition), 2012
Evidence for a role of Smad3 and Smad2 in stabilization of the tumor-derived mutant Smad2.Q407R.
Dumont E et al.
The Journal of Biological Chemistry, 2003
Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability.
Maurice D et al.
The Journal of Biological Chemistry, 2001
Formation of a stable heterodimer between Smad2 and Smad4.
Wu JW et al.
The Journal of Biological Chemistry, 2001
Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway.
Xu J et al.
Proceedings of the National Academy of Sciences of the United States of America, 2000
TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.
Hata A et al.
Molecular Medicine Today, 1998
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.
Eppert K et al.
Cell, 1996
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