Varaico: Literature-Extracted Genetic Variants

Gene:SMAD3
Variant:p.K378R
Back to variants list

SMAD3

NM_005902.4:p.K378R

Associated Papers

UBR5 mediates colorectal cancer chemoresistance by attenuating ferroptosis via Lys 11 ubiquitin-dependent stabilization of Smad3-SLC7A11 signaling.

Song M et al.

Redox Biology, 2024

Ubiquitin like protein FAT10 repressed cardiac fibrosis after myocardial ischemic via mediating degradation of Smad3 dependent on FAT10-proteasome system.

Chen C et al.

International Journal of Biological Sciences, 2023

pVHL-mediated SMAD3 degradation suppresses TGF-β signaling.

Zhou J et al.

The Journal of Cell Biology, 2022

Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice.

Maity S et al.

The Journal of Biological Chemistry, 2020

Acetylation of Smad2 by the co-activator p300 regulates activin and transforming growth factor beta response.

Tu AW et al.

The Journal of Biological Chemistry, 2007

Smad3 is acetylated by p300/CBP to regulate its transactivation activity.

Inoue Y et al.

Oncogene, 2007

The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation.

Simonsson M et al.

The Journal of Biological Chemistry, 2006

Roles for lysine residues of the MH2 domain of Smad3 in transforming growth factor-beta signaling.

Imoto S et al.

Febs Letters, 2005

Select a paper to view details
UCSC Genome Browser·Imprint·Privacy·Terms·Feedback·Email Updates·

Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."