Varaico: Literature-Extracted Genetic Variants

Gene:SMAD4
Variant:p.M4I
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SMAD4

NM_005359.6:p.M4I

Associated Papers

Prognostic and predictive implications of tumor suppressor gene alterations in non-small cell lung cancer.

Sposito M et al.

Scientific Reports, 2025

41053251 (PubMed )
Supplement: 41598_2025_18662_MOESM1_ESM.docx

Evaluation of Bridge Capture technology for mutation profiling in liquid biopsies of metastatic colorectal cancer patients.

Ganesan A et al.

Scientific Reports, 2025

Clinicopathological and molecular characterization of KRAS wild-type pancreatic ductal adenocarcinomas reveals precursor lesions with oncogenic mutations and fusions in RAS pathway genes.

Toriyama K et al.

The Journal of Pathology, 2025

40317966 (PubMed )
Supplement: PATH-266-337-s002.zip › path6432-sup-0002-TableS1S2S5-S7.xlsx › Table_S1

SMAD4 and KRAS Status Shapes Cancer Cell-Stromal Cross-Talk and Therapeutic Response in Pancreatic Cancer.

Lloyd EG et al.

Cancer Research, 2025

39841099 (PubMed )
Supplement: EMS202804-supplement-Table_1.xlsx › Table_S1

Somatic Genomic Profiling of Pancreatic Ductal Adenocarcinomas From a Diverse Cohort of Patients.

Riner AN et al.

Pancreas, 2025

Identification of TPI1 As a potential therapeutic target in pancreatic cancer with dependency of TP53 mutation using multi-omics analysis.

Toyoda T et al.

Cancer Science, 2024

39259678 (PubMed )
Supplement: CAS-115-3622-s005.xlsx › Supplementary_table8

Pan-Cancer Comparative and Integrative Analyses of Driver Alterations Using Japanese and International Genomic Databases.

Horie S et al.

Cancer Discovery, 2024

Japanese Society of Medical Oncology clinical guidelines: Molecular testing for colorectal cancer treatment, 5th edition.

Bando H et al.

Cancer Science, 2024

38263580 (PubMed )
Supplement: CAS-115-1014-s001.docx

Baseline mutational profiles of patients with carcinoma of unknown primary origin enrolled in the CUPISCO study.

Westphalen CB et al.

Esmo Open, 2023

37922692 (PubMed )
Supplement: mmc1.docx

ARID1A Mutation from Targeted Next-Generation Sequencing Predicts Primary Resistance to Gemcitabine and Cisplatin Chemotherapy in Advanced Biliary Tract Cancer.

Lee SH et al.

Cancer Research and Treatment, 2023

The targeted next-generation sequence revealed SMAD4, AKT1, and TP53 mutations from circulating cell-free DNA of breast cancer and its effect on protein structure - A computational approach.

Balasundaram A et al.

Journal of Biomolecular Structure & Dynamics, 2023

Clinicopathologic Characteristics and Outcomes for Patients With KRAS G12D-Mutant NSCLC.

Cooper AJ et al.

Jto Clinical and Research Reports, 2022

36118132 (PubMed )
Supplement: mmc2.docx

Potential genetic biomarker of Saudi Arabian patients with colorectal cancer.

Younis NS et al.

European Review for Medical and Pharmacological Sciences, 2022

Detection of circulating tumor DNA without a tumor-informed search using next-generation sequencing is a prognostic biomarker in pancreatic ductal adenocarcinoma.

Affolter KE et al.

Neoplasia (new York, N.y.), 2021

34298235 (PubMed )
Supplement: mmc1.docx

Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Li J et al.

Journal of Translational Medicine, 2020

Clinical Implication of Concordant or Discordant Genomic Profiling between Primary and Matched Metastatic Tissues in Patients with Colorectal Cancer.

Choi JY et al.

Cancer Research and Treatment, 2020

A novel hotspot and rare somatic mutation p.A138V, at TP53 is associated with poor survival of pancreatic ductal and periampullary adenocarcinoma patients.

Saha G et al.

Molecular Medicine (cambridge, Mass.), 2020

32552660 (PubMed )
Supplement: 10020_2020_183_MOESM8_ESM.xlsx › Sheet1

Genomic profiling of primary histiocytic sarcoma reveals two molecular subgroups.

Egan C et al.

Haematologica, 2020

Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer.

Belardinilli F et al.

Frontiers in Oncology, 2020

32457828 (PubMed )
Supplement: Table_1.xlsx › Table_S1

Targeted Sequencing Analysis of Pulmonary Adenocarcinoma with Multiple Synchronous Ground-Glass/Lepidic Nodules.

Park E et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2018

The neuroendocrine phenotype, genomic profile and therapeutic sensitivity of GEPNET cell lines.

Hofving T et al.

Endocrine-related Cancer, 2018

29444910 (PubMed )
Supplement: erc-25-309-t005.pdf

A KRAS wild type mutational status confers a survival advantage in pancreatic ductal adenocarcinoma.

Windon AL et al.

Journal of Gastrointestinal Oncology, 2018

Burden and Profile of Somatic Mutation in Duodenal Adenomas from Patients with Familial Adenomatous- and MUTYH-associated Polyposis.

Thomas LE et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2017

Profiling tumour heterogeneity through circulating tumour DNA in patients with pancreatic cancer.

Adamo P et al.

Oncotarget, 2017

Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms.

Yu J et al.

Gut, 2017

RET Aberrations in Diverse Cancers: Next-Generation Sequencing of 4,871 Patients.

Kato S et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2017

27683183 (PubMed )
Supplement: 10780432ccr161679-sup-168576_1_supp_3636667_wcc1ns.docx

Case report: Durable response to afatinib in a patient with lung cancer harboring two uncommon mutations of EGFR and a KRAS mutation.

Tanizaki J et al.

Lung Cancer (amsterdam, Netherlands), 2016

K-Ras mutation detection in liquid biopsy and tumor tissue as prognostic biomarker in patients with pancreatic cancer: a systematic review with meta-analysis.

Li T et al.

Medical Oncology (northwood, London, England), 2016

Molecular heterogeneity assessment by next-generation sequencing and response to gefitinib of EGFR mutant advanced lung adenocarcinoma.

Bria E et al.

Oncotarget, 2015

25904052 (PubMed )
Supplement: oncotarget-06-12783-s001.pdf

Somatic changes in primary liver cancer in Russia: a pilot study.

Kalinina O et al.

Mutation Research, 2013

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