Varaico: Literature-Extracted Genetic Variants

Gene:SMAD4
Variant:p.E49K
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SMAD4

NM_005359.6:p.E49K

Associated Papers

Clinicopathological and molecular characterization of KRAS wild-type pancreatic ductal adenocarcinomas reveals precursor lesions with oncogenic mutations and fusions in RAS pathway genes.

Toriyama K et al.

The Journal of Pathology, 2025

40317966 (PubMed )
Supplement: PATH-266-337-s002.zip › path6432-sup-0004-TableS4.xlsx › PDAC-038-ad

Prediction of response to anti-EGFR antibody-based therapies by multigene sequencing in colorectal cancer patients.

Lupini L et al.

Bmc Cancer, 2015

26508446 (PubMed )
Supplement: 12885_2015_1752_MOESM3_ESM.xlsx › Foglio1

An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity.

Xiao Z et al.

Oncogene, 2003

Importin beta mediates nuclear translocation of Smad 3.

Xiao Z et al.

The Journal of Biological Chemistry, 2000

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."