Associated Papers
RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer.
Jbara A et al.
Nature, 2023
Comparative Analysis of Genetic Alterations, HPV-Status, and PD-L1 Expression in Neuroendocrine Carcinomas of the Cervix.
Takayanagi D et al.
Cancers, 2021
Wip1 regulates Smad4 phosphorylation and inhibits TGF-β signaling.
Park DS et al.
Embo Reports, 2020
Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid.
Miller AM et al.
Nature, 2019
PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue.
Yokota T et al.
Bmc Cancer, 2018
Next generation sequencing of carcinoma of unknown primary reveals novel combinatorial strategies in a heterogeneous mutational landscape.
Subbiah IM et al.
Oncoscience, 2017
Point mutations in the tumor suppressor Smad4/DPC4 enhance its phosphorylation by GSK3 and reversibly inactivate TGF-β signaling.
Demagny H et al.
Molecular & Cellular Oncology, 2016
A Bayesian ensemble approach with a disease gene network predicts damaging effects of missense variants of human cancers.
Won HH et al.
Human Genetics, 2013
Structural and functional impact of cancer-related missense somatic mutations.
Shi Z et al.
Journal of Molecular Biology, 2011
Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor.
Nagashima K et al.
The Journal of Biological Chemistry, 2011
To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modifications.
Wrighton KH et al.
Cellular Signalling, 2008
A complex pattern of mutations and abnormal splicing of Smad4 is present in thyroid tumours.
Lazzereschi D et al.
Oncogene, 2005
Two somatic biallelic lesions within and near SMAD4 in a human breast cancer cell line.
Jakob J et al.
Genes, Chromosomes & Cancer, 2005
Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation.
Izzi L et al.
Oncogene, 2004
Tumor-derived C-terminal mutations of Smad4 with decreased DNA binding activity and enhanced intramolecular interaction.
Kuang C et al.
Oncogene, 2004
Differential ubiquitination defines the functional status of the tumor suppressor Smad4.
Morén A et al.
The Journal of Biological Chemistry, 2003
Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4.
Morén A et al.
Oncogene, 2000
Functional mapping of the MH1 DNA-binding domain of DPC4/SMAD4.
Jones JB et al.
Nucleic Acids Research, 2000
Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling.
Shi Y et al.
Cell, 1998
Evaluation of the FHIT gene in colorectal cancers.
Thiagalingam S et al.
Cancer Research, 1996
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers.
Thiagalingam S et al.
Nature Genetics, 1996
Higher TP53 somatic mutation prevalence from liquid biopsy analysis in ever smoker non-small-cell lung cancer patients.
Erdem HB et al.
Mutation Research, 0