Varaico: Literature-Extracted Genetic Variants

Gene:SMAD4
Variant:p.K507R
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SMAD4

NM_005359.6:p.K507R

Associated Papers

FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.

Dupont S et al.

Cell, 2009

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases.

Morén A et al.

The Journal of Biological Chemistry, 2005

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

Morén A et al.

The Journal of Biological Chemistry, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."