Associated Papers
Active site assembly by SMG5 as a mechanism for SMG6 endonuclease licensing in nonsense-mediated mRNA decay.
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Journal of Molecular Biology, 2026
Composite SMG5-SMG6 PIN domain formation is essential for NMD.
Kurscheidt K et al.
Nature Communications, 2026
Structure of the Nmd4-Upf1 complex supports conservation of the nonsense-mediated mRNA decay pathway between yeast and humans.
Barbarin-Bocahu I et al.
Plos Biology, 2024
Coupled protein quality control during nonsense-mediated mRNA decay.
Inglis AJ et al.
Journal of Cell Science, 2023
Treatment of type 1 myotonic dystrophy by engineering site-specific RNA endonucleases that target (CUG)(n) repeats.
Zhang W et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy, 2014
SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells.
Eberle AB et al.
Nature Structural & Molecular Biology, 2009
Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex.
Glavan F et al.
The Embo Journal, 2006
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