Associated Papers
HnRNPR strongly represses splicing of a critical exon associated with spinal muscular atrophy through binding to an exonic AU-rich element.
Jiang T et al.
Journal of Medical Genetics, 2023
A splicing silencer in SMN2 intron 6 is critical in spinal muscular atrophy.
Wang L et al.
Human Molecular Genetics, 2023
Structural Context of a Critical Exon of Spinal Muscular Atrophy Gene.
Singh NN et al.
Frontiers in Molecular Biosciences, 2022
RNA in spinal muscular atrophy: therapeutic implications of targeting.
Singh RN et al.
Expert Opinion on Therapeutic Targets, 2020
Mechanism of Splicing Regulation of Spinal Muscular Atrophy Genes.
Singh RN et al.
Advances in Neurobiology, 2018
Splicing regulation in spinal muscular atrophy by an RNA structure formed by long-distance interactions.
Singh NN et al.
Annals of the New York Academy of Sciences, 2015
Advances in therapeutic development for spinal muscular atrophy.
Howell MD et al.
Future Medicinal Chemistry, 2014
An intronic structure enabled by a long-distance interaction serves as a novel target for splicing correction in spinal muscular atrophy.
Singh NN et al.
Nucleic Acids Research, 2013
Hypoxia is a modifier of SMN2 splicing and disease severity in a severe SMA mouse model.
Bebee TW et al.
Human Molecular Genetics, 2012
Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice.
Hua Y et al.
American Journal of Human Genetics, 2008
Alternative splicing in spinal muscular atrophy underscores the role of an intron definition model.
Singh NN et al.
Rna Biology, 0
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