Varaico: Literature-Extracted Genetic Variants

Gene:SMO
Variant:p.D473G
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SMO

NM_005631.5:p.D473G

Associated Papers

Hedgehog signalling pathway inhibitors in the treatment of basal cell carcinoma: an updated review.

Markota Cagalj A et al.

Journal of Drug Targeting, 2025

ProTarget: a Danish Nationwide Clinical Trial on Targeted Cancer Treatment based on genomic profiling - a national, phase 2, prospective, multi-drug, non-randomized, open-label basket trial.

Kringelbach T et al.

Bmc Cancer, 2023

The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.

Punta M et al.

Frontiers in Immunology, 2020

33133066 (PubMed )
Supplement: Table_1.xlsx › Resistance-no-BCR-ABL1

SOX9 Transcriptionally Regulates mTOR-Induced Proliferation of Basal Cell Carcinomas.

Kim AL et al.

The Journal of Investigative Dermatology, 2018

A computational study of hedgehog signalling involved in basal cell carcinoma reveals the potential and limitation of combination therapy.

Buetti-Dinh A et al.

Bmc Cancer, 2018

Reprogramming Medulloblastoma-Propagating Cells by a Combined Antagonism of Sonic Hedgehog and CXCR4.

Ward SA et al.

Cancer Research, 2017

AKT1 Activation is Obligatory for Spontaneous BCC Tumor Growth in a Murine Model that Mimics Some Features of Basal Cell Nevus Syndrome.

Kim AL et al.

Cancer Prevention Research (philadelphia, Pa.), 2016

Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma.

Atwood SX et al.

The Journal of Investigative Dermatology, 2015

Common Variants Affecting Susceptibility to Develop Multiple Basal Cell Carcinomas.

Verkouteren JAC et al.

The Journal of Investigative Dermatology, 2015

Smoothened variants explain the majority of drug resistance in basal cell carcinoma.

Atwood SX et al.

Cancer Cell, 2015

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

Yauch RL et al.

Science (new York, N.y.), 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."