Associated Papers
PIPKI-PIP2 promotes cell migration by recruiting Smurf1 to the membrane and increasing its activity.
Chen Y et al.
Acta Biochimica Et Biophysica Sinica, 2025
CYYR1 promotes the degradation of the E3 ubiquitin ligase WWP1 and is associated with favorable prognosis in breast cancer.
Perron T et al.
The Journal of Biological Chemistry, 2024
SMURF1 controls the PPP3/calcineurin complex and TFEB at a regulatory node for lysosomal biogenesis.
Xia Q et al.
Autophagy, 2024
Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to attenuate their tumor-suppressor functions.
Xu Y et al.
The Journal of Biological Chemistry, 2023
Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy.
Xia Q et al.
Cell & Bioscience, 2023
E3 ligase Smurf1 protects against misfolded SOD1 in neuronal cells by promoting its K63 ubiquitylation and aggresome formation.
Dong L et al.
Human Molecular Genetics, 2022
Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62-dependent manner.
Han D et al.
Febs Open Bio, 2022
Smurf1 aggravates non-alcoholic fatty liver disease by stabilizing SREBP-1c in an E3 activity-independent manner.
Zhang X et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2020
Molecular Analysis of Membrane Targeting by the C2 Domain of the E3 Ubiquitin Ligase Smurf1.
Scott JL et al.
Biomolecules, 2020
Monoubiquitination of p120-catenin is essential for TGFβ-induced epithelial-mesenchymal transition and tumor metastasis.
Wu Q et al.
Science Advances, 2020
Protective Effect of SMAD-Specific E3 Ubiquitin Protein Ligase 1 in Alcoholic Steatohepatitis in Mice.
Petrasek J et al.
Hepatology Communications, 2019
VCP/p97 increases BMP signaling by accelerating ubiquitin ligase Smurf1 degradation.
Li H et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2019
Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis.
Zhu K et al.
Plos Biology, 2018
Smad ubiquitylation regulatory factor 1 promotes LIM-homeobox gene 9 degradation and represses testosterone production in Leydig cells.
Hu F et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2018
Smurf1 restricts the antiviral function mediated by USP25 through promoting its ubiquitination and degradation.
Qian G et al.
Biochemical and Biophysical Research Communications, 2018
Smurf1 targets Securin for ubiquitin-dependent degradation and regulates the metaphase-to-anaphase transition.
Wei R et al.
Cellular Signalling, 2017
Smurf1 controls S phase progression and tumorigenesis through Wee1 degradation.
Wei R et al.
Febs Letters, 2017
Smurf1 represses TNF-α production through ubiquitination and destabilization of USP5.
Qian G et al.
Biochemical and Biophysical Research Communications, 2016
ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance.
Wang M et al.
Nature Communications, 2014
Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.
Xie Y et al.
The Journal of Biological Chemistry, 2013
Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling.
Lee YS et al.
Nature Communications, 2011
Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity.
Tian M et al.
Febs Letters, 2011
SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.
Cui Y et al.
The Embo Journal, 2011
SMURF1 amplification promotes invasiveness in pancreatic cancer.
Kwei KA et al.
Plos One, 2011
REGgamma proteasome mediates degradation of the ubiquitin ligase Smurf1.
Nie J et al.
Febs Letters, 2010
HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation.
Nie J et al.
Febs Letters, 2010