Varaico: Literature-Extracted Genetic Variants

Gene:SNAP25
Variant:p.S187A
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SNAP25

NM_130811.4:p.S187A

Associated Papers

Deficiency of PKA-mediated SNAP-25b phosphorylation destabilizes exocytotic fusion pores and reduces the interactions of t-SNAREs.

Hsiao YT et al.

The Journal of Physiology, 2025

Vesicle trafficking with snares: a perspective for autism.

Özdemir Ç et al.

Molecular Biology Reports, 2022

SNAREs and developmental disorders.

Tang BL

Journal of Cellular Physiology, 2021

Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy.

Kovacevic J et al.

Brain : a Journal of Neurology, 2018

Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.

Lahut S et al.

Disease Models & Mechanisms, 2017

Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice.

Ohira K et al.

Molecular Brain, 2013

A single amino acid mutation in SNAP-25 induces anxiety-related behavior in mouse.

Kataoka M et al.

Plos One, 2011

Presynaptic signaling by heterotrimeric G-proteins.

Brown DA et al.

Handbook of Experimental Pharmacology, 2008

Phosphomimetic mutation of Ser-187 of SNAP-25 increases both syntaxin binding and highly Ca2+-sensitive exocytosis.

Yang Y et al.

The Journal of General Physiology, 2007

Abstracts of the 45th Annual Meeting of the Japanese Society for Neurochemistry. Sapporo, Japan. July 17-19, 2002.

Unknown Author

Neurochemical Research, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."