Varaico: Literature-Extracted Genetic Variants

Gene:SNAP25
Variant:p.S187C
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SNAP25

NM_130811.4:p.S187C

Associated Papers

A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis.

Zhao K et al.

Proceedings of the National Academy of Sciences of the United States of America, 2025

Structural and Functional Analysis of the CAPS SNARE-Binding Domain Required for SNARE Complex Formation and Exocytosis.

Zhou H et al.

Cell Reports, 2019

Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly.

Wang S et al.

Nature Communications, 2019

30622273 (PubMed )
Supplement: 41467_2018_8028_MOESM1_ESM.pdf

Tomosyn guides SNARE complex formation in coordination with Munc18 and Munc13.

Li Y et al.

Febs Letters, 2018

A Stimulation Function of Synaptotagmin-1 in Ternary SNARE Complex Formation Dependent on Munc18 and Munc13.

Li Y et al.

Frontiers in Molecular Neuroscience, 2017

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming.

Yang X et al.

Nature Structural & Molecular Biology, 2015

Phosphomimetic mutation of Ser-187 of SNAP-25 increases both syntaxin binding and highly Ca2+-sensitive exocytosis.

Yang Y et al.

The Journal of General Physiology, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."