Associated Papers
Parkinson's disease-specific α-Synuclein variants potentially drive Lewy body formation by engaging in promiscuous and non-functional interactions.
Jos S et al.
Communications Biology, 2026
The Aggregation Continuum of α-Synuclein and Its Relevance to Brain Aging.
Rana A et al.
Acs Chemical Neuroscience, 2025
PLK2 disrupts autophagic flux to promote SNCA/α-synuclein pathology.
Zhang C et al.
Autophagy, 2025
Characterization and Regulation of Alpha-Synuclein Phosphorylation in Enteric Neurons.
Pinard G et al.
The European Journal of Neuroscience, 2025
Formation of seeding-competent α-synuclein aggregates in parkin-deficient iPSC-derived human neurons.
Schmidt SI et al.
Npj Parkinson's Disease, 2025
Structural and functional insights into the nuclear role of Parkinson's disease-associated α-synuclein as a histone chaperone.
Jos S et al.
Communications Biology, 2025
Alpha-Synuclein Phosphomimetic Y39E and S129D Knock-In Mice Show Cytosolic Alpha-Synuclein Localization without Developing Neurodegeneration or Motor Deficits.
Kim Y et al.
Eneuro, 2025
Experimental Evidence for Phosphorylation-Driven Allosteric Regulation of Alpha Synuclein Function.
Dollar AN et al.
Biorxiv : the Preprint Server for Biology, 2025
Bridging the gap: investigating the role of phosphorylation at the serine 129 site of α-synuclein in VAPB-PTPIP51 interactions.
Liu W et al.
Acta Neuropathologica Communications, 2025
Serine-129 phosphorylated α-synuclein drives mitochondrial dysfunction and calcium dysregulation in Parkinson's disease model.
Jiao J et al.
Frontiers in Aging Neuroscience, 2025
Posttranslational Modifications of α-Synuclein, Their Therapeutic Potential, and Crosstalk in Health and Neurodegenerative Diseases.
Hassanzadeh K et al.
Pharmacological Reviews, 2024
Alpha-synuclein modulates the repair of genomic DNA double-strand breaks in a DNA-PKcs-regulated manner.
Rose EP et al.
Neurobiology of Disease, 2024
RXR nuclear receptor signaling modulates lipid metabolism and triggers lysosomal clearance of alpha-synuclein in neuronal models of synucleinopathy.
Tripathi A et al.
Cellular and Molecular Life Sciences : Cmls, 2024
Alpha-synuclein regulates the repair of genomic DNA double-strand breaks in a DNA-PKcs-dependent manner.
Rose EP et al.
Biorxiv : the Preprint Server for Biology, 2024
Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function.
Parra-Rivas LA et al.
Neuron, 2023
Dynamic reversibility of α-synuclein serine-129 phosphorylation is impaired in synucleinopathy models.
Ramalingam N et al.
Embo Reports, 2023
Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation.
Zenko D et al.
Science Advances, 2023
Postsynaptic synucleins mediate endocannabinoid signaling.
Albarran E et al.
Nature Neuroscience, 2023
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.
Ramalingam N et al.
Npj Parkinson's Disease, 2023
Single point mutations at the S129 residue of α-synuclein and their effect on structure, aggregation, and neurotoxicity.
Pandit E et al.
Frontiers in Chemistry, 2023
Protein kinase R dependent phosphorylation of α-synuclein regulates its membrane binding and aggregation.
Reimer L et al.
Pnas Nexus, 2022
Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies.
Kawahata I et al.
International Journal of Molecular Sciences, 2022
Animal models of brain-first and body-first Parkinson's disease.
Van Den Berge N et al.
Neurobiology of Disease, 2022
Parkinson's Disease Modification Through Abl Kinase Inhibition: An Opportunity.
Werner MH et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2022
Alpha-Synuclein and Cognitive Decline in Parkinson Disease.
Fan TS et al.
Life (basel, Switzerland), 2021
CK1BP Reduces α-Synuclein Oligomerization and Aggregation Independent of Serine 129 Phosphorylation.
Elsholz L et al.
Cells, 2021
α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast.
Popova B et al.
Cells, 2021
Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons.
Tanudjojo B et al.
Nature Communications, 2021
In vivo aggregation of presynaptic alpha-synuclein is not influenced by its phosphorylation at serine-129.
Weston LJ et al.
Neurobiology of Disease, 2021
Genes Implicated in Familial Parkinson's Disease Provide a Dual Picture of Nigral Dopaminergic Neurodegeneration with Mitochondria Taking Center Stage.
Franco R et al.
International Journal of Molecular Sciences, 2021
Reverse engineering Lewy bodies: how far have we come and how far can we go?
Fares MB et al.
Nature Reviews. Neuroscience, 2021
Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs.
Shrivastava AN et al.
Biophysical Journal, 2020
Current Evidence for a Bidirectional Loop Between the Lysosome and Alpha-Synuclein Proteoforms.
Wildburger NC et al.
Frontiers in Cell and Developmental Biology, 2020
Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders.
Schaser AJ et al.
Scientific Reports, 2019
O-GlcNAc Modification Protects against Protein Misfolding and Aggregation in Neurodegenerative Disease.
Ryan P et al.
Acs Chemical Neuroscience, 2019
Genetically engineered animal models of Parkinson's disease: From worm to rodent.
Breger LS et al.
The European Journal of Neuroscience, 2019
Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay.
Cariulo C et al.
Frontiers in Neuroscience, 2019
α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton.
Ordonez DG et al.
Neuron, 2018
Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease.
Rocha EM et al.
Neurobiology of Disease, 2018
Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice.
Karampetsou M et al.
Scientific Reports, 2017
Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport.
Toba S et al.
Scientific Reports, 2017
Polo-like kinase 2 modulates α-synuclein protein levels by regulating its mRNA production.
Kofoed RH et al.
Neurobiology of Disease, 2017