Varaico: Literature-Extracted Genetic Variants

Gene:SNCA
Variant:p.D98A
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SNCA

NM_000345.4:p.D98A

Associated Papers

Defining essential charged residues in fibril formation of a lysosomal derived N-terminal α-synuclein truncation.

McGlinchey RP et al.

Nature Communications, 2025

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation.

Kunadt M et al.

Acta Neuropathologica, 2015

Sumoylation inhibits alpha-synuclein aggregation and toxicity.

Krumova P et al.

The Journal of Cell Biology, 2011

Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease.

Schneider L et al.

Molecular Neurodegeneration, 2010

Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.

Cullen V et al.

Molecular Brain, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."