Associated Papers
Biobank-scale genetic characterization of Alzheimer's disease and related dementias across diverse ancestries.
Khani M et al.
Nature Communications, 2025
Biobank-scale characterization of Alzheimer's disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestries.
Khani M et al.
Medrxiv : the Preprint Server for Health Sciences, 2024
Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation.
Zenko D et al.
Science Advances, 2023
The Ala53Thr Mutation in the α-Synuclein Gene in an Indian Patient with Young-Onset Parkinson's Disease.
Pandey S et al.
Movement Disorders Clinical Practice, 2021
A population scale analysis of rare SNCA variation in the UK Biobank.
Blauwendraat C et al.
Neurobiology of Disease, 2021
Systematic Analysis of the Genetic Variability That Impacts SUMO Conjugation and Their Involvement in Human Diseases.
Xu HD et al.
Scientific Reports, 2015
Interplay between sumoylation and phosphorylation for protection against α-synuclein inclusions.
Shahpasandzadeh H et al.
The Journal of Biological Chemistry, 2014
Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.
Lázaro DF et al.
Plos Genetics, 2014
[The effect of small ubiquitin-like modifier-1 modification on the formation of Lewy body-like inclusions in cytoplasm and apoptosis of HEK293 cell induced by overexpression and mutation of alpha-synuclein].
Chen T et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 2011
Sumoylation inhibits alpha-synuclein aggregation and toxicity.
Krumova P et al.
The Journal of Cell Biology, 2011
[Effect of SUMO-1 on mitochondria subcellular localization of alpha-synuclein and its degradation via ubiquitin-proteasome system].
Chen T et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 2010
Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells.
Rott R et al.
The Journal of Biological Chemistry, 2008
Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein.
Dorval V et al.
The Journal of Biological Chemistry, 2006