Associated Papers
In vitro-prepared A30P alpha-synuclein fibrils adopt the conserved and disease-relevant Greek key fold.
Milchberg MH et al.
Biorxiv : the Preprint Server for Biology, 2026
Unfolding Sequence-Specific Enigma in Monomeric α-Synuclein: Implications for Parkinson's Disease.
Ranjan P et al.
Acs Chemical Neuroscience, 2026
Hydrophobic residues in the α-synuclein NAC domain drive seed-competent fibril formation and are targeted by peptide inhibitors.
Das V et al.
The Febs Journal, 2026
A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features.
Brücke C et al.
Molecular Neurodegeneration, 2025
Amyloid formation of alternatively spliced variants of α-synuclein.
SanGiovanni DQ et al.
Protein Science : a Publication of the Protein Society, 2025
A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features.
Brücke C et al.
Medrxiv : the Preprint Server for Health Sciences, 2025
Glycine-to-aspartic acid mutation at codon 51 in Snca disrupts the synaptic localisation of α-synuclein and enhances its propensity for synucleinopathy.
West S et al.
Brain Communications, 2025
α-Synuclein in Parkinson's Disease: 12 Years Later.
Vekrellis K et al.
Cold Spring Harbor Perspectives in Medicine, 2024
Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases.
Sokratian A et al.
Science Advances, 2024
Structurally targeted mutagenesis identifies key residues supporting α-synuclein misfolding in multiple system atrophy.
Reis PM et al.
Journal of Parkinson's Disease, 2024
A new genetic variant, presenting as young onset rapidly progressive dementia and parkinsonism.
Eissazade N et al.
Parkinsonism & Related Disorders, 2024
Expert Commentary: A new genetic variant, presenting as young onset rapidly progressive dementia and parkinsonism.
Uribe Roca MC
Parkinsonism & Related Disorders, 2024
Structurally targeted mutagenesis identifies key residues supporting α -synuclein misfolding in multiple system atrophy.
Reis PM et al.
Biorxiv : the Preprint Server for Biology, 2024
Liquid-liquid phase separation of α-synuclein is highly sensitive to sequence complexity.
Mahapatra A et al.
Protein Science : a Publication of the Protein Society, 2024
Liquid-liquid phase separation of α-synuclein is highly sensitive to sequence complexity.
Mahapatra A et al.
Biorxiv : the Preprint Server for Biology, 2023
Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein.
Ohgita T et al.
Scientific Reports, 2023
Functional and Pathological Effects of α-Synuclein on Synaptic SNARE Complexes.
Gao V et al.
Journal of Molecular Biology, 2023
The E46K mutation modulates α-synuclein prion replication in transgenic mice.
Holec SAM et al.
Plos Pathogens, 2022
Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43.
Tarutani A et al.
Acta Neuropathologica, 2022
A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity.
Kumar ST et al.
Science Advances, 2022
Clinical Manifestations and Molecular Backgrounds of Parkinson's Disease Regarding Genes Identified From Familial and Population Studies.
Nishioka K et al.
Frontiers in Neurology, 2022
A new alpha-synuclein missense variant (Thr72Met) in two Turkish families with Parkinson's disease.
Fevga C et al.
Parkinsonism & Related Disorders, 2021
A novel SNCA E83Q mutation in a case of dementia with Lewy bodies and atypical frontotemporal lobar degeneration.
Kapasi A et al.
Neuropathology : Official Journal of the Japanese Society of Neuropathology, 2020