Varaico: Literature-Extracted Genetic Variants

Gene:SNCA
Variant:p.A76E
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SNCA

NM_000345.4:p.A76E

Associated Papers

Transcriptional mutagenesis of α-synuclein caused by DNA oxidation in Parkinson's disease pathogenesis.

Basu S et al.

Acta Neuropathologica, 2023

Contribution of Alanine-76 and Serine Phosphorylation in α-Synuclein Membrane Association and Aggregation in Yeasts.

Fiske M et al.

Parkinson's Disease, 2011

Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization.

Waxman EA et al.

Biochemistry, 2009

Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity.

Volles MJ et al.

Journal of Molecular Biology, 2007

A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

Giasson BI et al.

The Journal of Biological Chemistry, 2001

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."