Associated Papers
Sterile innate immune mechanisms in neurodegenerative diseases.
Ealy A et al.
The Journal of Biological Chemistry, 2026
Quantifying the Acute Toxicity of Alpha-Synuclein Membrane-Accumulation in a Cell-Based Assay.
Li B et al.
Research Square, 2026
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease.
Eubanks E et al.
Cell Reports, 2025
Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson's disease.
Yan S et al.
Cell Reports. Medicine, 2025
Stearoyl-CoA desaturase-1: a potential therapeutic target for neurological disorders.
Loix M et al.
Molecular Neurodegeneration, 2024
Altered Protein Palmitoylation as Disease Mechanism in Neurodegenerative Disorders.
Wlodarczyk J et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2024
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions.
Lam I et al.
Neuron, 2024
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease.
Eubanks E et al.
Biorxiv : the Preprint Server for Biology, 2024
Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes.
Nuber S et al.
Npj Parkinson's Disease, 2024
Adding hydrophobicity or positive charges to the cytosolic half of the α-synuclein 3-11 helix increases membrane association and S129 phosphorylation.
Shimanaka K et al.
Febs Letters, 2024
Dynamic reversibility of α-synuclein serine-129 phosphorylation is impaired in synucleinopathy models.
Ramalingam N et al.
Embo Reports, 2023
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.
He Y et al.
Nature Communications, 2023
Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation.
Zenko D et al.
Science Advances, 2023
The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.
Hallacli E et al.
Cell, 2022
Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis.
Tripathi A et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2022
Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity.
Kim TE et al.
Human Molecular Genetics, 2021
Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease.
Fonseca-Ornelas L et al.
Cell Reports, 2021
Crowded organelles, lipid accumulation, and abnormal membrane tubulation in cellular models of enhanced α-synuclein membrane interaction.
Ericsson M et al.
Brain Research, 2021
Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity.
Ho GPH et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2021
A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.
Nuber S et al.
Annals of Neurology, 2021
Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.
Terry-Kantor E et al.
International Journal of Molecular Sciences, 2020
The Role of Lipids in the Initiation of α-Synuclein Misfolding.
Kiechle M et al.
Frontiers in Cell and Developmental Biology, 2020
Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.
Imberdis T et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019
E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity.
Rovere M et al.
The Journal of Biological Chemistry, 2019
Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease.
Nuber S et al.
Neuron, 2018
Cryo-EM structure of alpha-synuclein fibrils.
Guerrero-Ferreira R et al.
Elife, 2018
Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.
Dettmer U et al.
Human Molecular Genetics, 2017
The effect of amino acid substitution in the imperfect repeat sequences of alpha-synuclein on fibrillation.
Harada R et al.
Biochimica Et Biophysica Acta, 2009
Sequence determinants regulating fibrillation of human alpha-synuclein.
Koo HJ et al.
Biochemical and Biophysical Research Communications, 2008