Associated Papers
An update on the monogenic causes of Parkinson's disease: Impact on patient stratification and personalised medicine.
Asmi S et al.
Ageing Research Reviews, 2026
CPEB3 selectively inhibits α-synuclein aggregation without modulating TDP-43 pathology.
Babu AT et al.
Febs Letters, 2026
SNCA (α-synuclein) H50Q mutation reveals distinct neurodegenerative patterns and adaptive responses in Parkinson's disease Drosophila model.
Samson JS et al.
Biochemical and Biophysical Research Communications, 2026
Multifaceted performances of α-synuclein in health and neurological diseases.
Wang M et al.
Neuroscience, 2026
In vitro-prepared A30P alpha-synuclein fibrils adopt the conserved and disease-relevant Greek key fold.
Milchberg MH et al.
Biorxiv : the Preprint Server for Biology, 2026
Unfolding Sequence-Specific Enigma in Monomeric α-Synuclein: Implications for Parkinson's Disease.
Ranjan P et al.
Acs Chemical Neuroscience, 2026
Hidden faces of alpha-synuclein: Cryo-EM revelation of fibril polymorphs driven by disease, mutations, and PTMs.
Pirhaghi M et al.
Bba Advances, 2026
Cholesterol modulates vesicle clustering mediated by alpha-synuclein in a nonlinear fashion.
Tyoe O et al.
Biophysics Reports, 2025
Neuropathology in genetic Parkinson's disease: a focused review of pathological and clinical findings.
Barbosa PM et al.
Journal of Neural Transmission (vienna, Austria : 1996), 2025
Rising Stars: Molecular Mechanisms and Chemical Interventions of α-Synuclein Amyloid Aggregation in Parkinson's Disease.
Zhang S et al.
Journal of Molecular Biology, 2025
Familial mutations modulate α-synuclein interactions with key neuronal membrane lipids.
Ali A et al.
The Febs Journal, 2025
The Yeast Parkinson's Disease Model Exhibits An Increase in Peroxisome Number Independent of the Division Proteins Vps1 and Dnm1.
Sarhadi TR et al.
Molecular Neurobiology, 2025
A Novel α-Synuclein K58N Missense Variant in a Patient with Parkinson's Disease.
Al-Azzani M et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2025
Alpha-Synuclein Neurobiology in Parkinson's Disease: A Comprehensive Review of Its Role, Mechanisms, and Therapeutic Perspectives.
Pitton Rissardo J et al.
Brain Sciences, 2025
Protein aggregation in neurodegenerative diseases.
Wang J et al.
Chinese Medical Journal, 2025
Parkinson disease is a fatty acidopathy.
Fanning S et al.
Nature Reviews. Neurology, 2025
Carbamylation Promotes Sequence-Specific Amyloidogenesis in the α-Synuclein KTKEGV Repeat Motifs.
Gadhavi J et al.
Acs Chemical Neuroscience, 2025
The Aggregation Continuum of α-Synuclein and Its Relevance to Brain Aging.
Rana A et al.
Acs Chemical Neuroscience, 2025
Genetic and structural aspects of amyloid diseases.
Rosenberg GM et al.
Science Translational Medicine, 2025
A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features.
Brücke C et al.
Molecular Neurodegeneration, 2025
Molecular Dynamics Simulations Reveal Conformational Determinants of the Dynamic Association between α-Synuclein and Membranes.
Huang J et al.
Journal of Chemical Information and Modeling, 2025
Modeling Synucleinopathy Using hESC-Derived Cerebral Organoids.
Kim SJ et al.
Cells, 2025
Conformational Ensemble Dynamics of Intrinsically Disordered Full-Length α- and β-Synuclein Monomers.
Lv Z et al.
Journal of Chemical Information and Modeling, 2025
Isobavachalcone inhibits α-synuclein fibrillogenesis and its Parkinson's disease variants, disassembles the mature fibrils and alleviates cellular toxicity.
Xie F et al.
International Journal of Biological Macromolecules, 2025
Interaction Between α-Synuclein and DJ-1 in Parkinson's Disease.
Sobhifar P et al.
Brain Sciences, 2025
Biobank-scale genetic characterization of Alzheimer's disease and related dementias across diverse ancestries.
Khani M et al.
Nature Communications, 2025
Computational association in parkinson's disease SNPs with brain structural and functional alterations.
Subramaniyan S et al.
Neurogenetics, 2025
Cognitive Decline in Parkinsonism: From Clinical Phenotypes to the Genetic Background.
Koros C et al.
Biomedicines, 2025
USP10 inhibits the degradation of α-synuclein, a pathogenic factor associated with Parkinson's disease, by inhibiting chaperone-mediated autophagy.
Anisimov S et al.
The Journal of Biological Chemistry, 2025
Amyloid formation of alternatively spliced variants of α-synuclein.
SanGiovanni DQ et al.
Protein Science : a Publication of the Protein Society, 2025
Alpha-Synuclein drives NURR1 and NLRP3 Inflammasome dysregulation in Parkinson's disease: From pathogenesis to potential therapeutic strategies.
Abdelaziz AM
International Immunopharmacology, 2025
Effect of hydrogen sulfide on alpha-synuclein aggregation and cell viability.
Ostrakhovitch EA et al.
Scientific Reports, 2025
Sphingolipidoses: expanding the spectrum of α-synucleinopathies.
Erskine D et al.
Journal of Neural Transmission (vienna, Austria : 1996), 2025
Population-Specific Differences in Pathogenic Variants of Genes Associated with Monogenic Parkinson's Disease.
Flores-Ocampo V et al.
Genes, 2025
Outlook of SNCA (α-synuclein) transgenic fly models in delineating the sequel of mitochondrial dysfunction in Parkinson's disease.
Samson JS et al.
Brain Research, 2025
H50Q mutation in alpha-Synuclein impairs the insulin signaling pathway and induces neuroinflammation in the Drosophila model.
Rai P et al.
Experimental Cell Research, 2025
Unveiling the significance of synaptic proteins in parkinson's pathogenesis: A review.
Soni R et al.
International Journal of Biological Macromolecules, 2025
Alpha-Synuclein Pathophysiology in Neurodegenerative Disorders: A Review Focusing on Molecular Mechanisms and Treatment Advances in Parkinson's Disease.
Yaribash S et al.
Cellular and Molecular Neurobiology, 2025
A personalised and comprehensive approach is required to suppress or replenish SNCA for Parkinson's disease.
Li D et al.
Npj Parkinson's Disease, 2025
A novel alpha-synuclein K58N missense variant in a patient with Parkinson's disease.
Al-Azzani M et al.
Medrxiv : the Preprint Server for Health Sciences, 2025
A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features.
Brücke C et al.
Medrxiv : the Preprint Server for Health Sciences, 2025
High-resolution Cryo-EM Structure Determination of a-Synuclein-A Prototypical Amyloid Fibril.
Sanchez JC et al.
Bio-protocol, 2025
The role of Nα-terminal acetylation in protein conformation.
Calis S et al.
The Febs Journal, 2025
The novel p.A30G SNCA pathogenic variant in Greek patients with familial and sporadic Parkinson's disease.
Alefanti I et al.
European Journal of Neurology, 2025