Associated Papers
Degradation of alpha-synuclein/SNCA mRNA by RNautophagy.
Kabuta C et al.
Neurochemistry International, 2026
SNCA (α-synuclein) H50Q mutation reveals distinct neurodegenerative patterns and adaptive responses in Parkinson's disease Drosophila model.
Samson JS et al.
Biochemical and Biophysical Research Communications, 2026
Multifaceted performances of α-synuclein in health and neurological diseases.
Wang M et al.
Neuroscience, 2026
In vitro-prepared A30P alpha-synuclein fibrils adopt the conserved and disease-relevant Greek key fold.
Milchberg MH et al.
Biorxiv : the Preprint Server for Biology, 2026
Sterile innate immune mechanisms in neurodegenerative diseases.
Ealy A et al.
The Journal of Biological Chemistry, 2026
Differential roles of proteasome and autophagy in α-synuclein and E46K oligomer clearance: insight into the modulatory effects of the dopamine metabolite DOPAC.
Leri M et al.
International Journal of Biological Macromolecules, 2026
Neuroimmune Interactions in Neurodegeneration: The Role of Microglia in Alzheimer's and Parkinson's Disease Pathogenesis.
Goyal P et al.
Brain Sciences, 2026
Genetic predispositions and nutritional strategies: a review of nutrigenomics in Parkinson's disease.
Mohamed YA et al.
Neuroscience, 2026
Quantifying the Acute Toxicity of Alpha-Synuclein Membrane-Accumulation in a Cell-Based Assay.
Li B et al.
Research Square, 2026
NRF2 AT THE CROSSROADS OF PARKINSON'S DISEASE AND AGING: MECHANISTIC INSIGHTS AND TRANSLATIONAL PERSPECTIVES.
Áj GY et al.
Free Radical Biology & Medicine, 2026
Heteroaggregation of Wild-Type and ALS Mutant SOD1.
Dashnaw CM et al.
Acs Chemical Neuroscience, 2026
Unfolding Sequence-Specific Enigma in Monomeric α-Synuclein: Implications for Parkinson's Disease.
Ranjan P et al.
Acs Chemical Neuroscience, 2026
Hydrophobic residues in the α-synuclein NAC domain drive seed-competent fibril formation and are targeted by peptide inhibitors.
Das V et al.
The Febs Journal, 2026
Diosgenin reduces β-sheet content in mutated α-syn aggregation: Insights from conformational dynamics at intracellular and extracellular neuronal salt concentrations.
Nandeshwar et al.
Journal of Molecular Graphics & Modelling, 2026
Hidden faces of alpha-synuclein: Cryo-EM revelation of fibril polymorphs driven by disease, mutations, and PTMs.
Pirhaghi M et al.
Bba Advances, 2026
Cholesterol modulates vesicle clustering mediated by alpha-synuclein in a nonlinear fashion.
Tyoe O et al.
Biophysics Reports, 2025
Residue-Specific Modulation of Aggregation-Associated Interactions by Spermine in Tau, α-Synuclein, and Aβ40.
Saha D et al.
Biorxiv : the Preprint Server for Biology, 2025
GM1 and OligoGM1 Drive Divergent α-Synuclein Aggregation Pathways.
Vasti C et al.
Langmuir : the Acs Journal of Surfaces and Colloids, 2025
Neuropathology in genetic Parkinson's disease: a focused review of pathological and clinical findings.
Barbosa PM et al.
Journal of Neural Transmission (vienna, Austria : 1996), 2025
Synaptic Vesicle Disruption in Parkinson's Disease: Dual Roles of α-Synuclein and Emerging Therapeutic Targets.
Treviño M et al.
Brain Sciences, 2025
Rising Stars: Molecular Mechanisms and Chemical Interventions of α-Synuclein Amyloid Aggregation in Parkinson's Disease.
Zhang S et al.
Journal of Molecular Biology, 2025
Familial mutations modulate α-synuclein interactions with key neuronal membrane lipids.
Ali A et al.
The Febs Journal, 2025
Human Wild-Type α-Synuclein Drives Progressive Tau Pathology in a Disease-Relevant Mouse Model of Synucleinopathy.
Senapati S et al.
Research Square, 2025
A Novel α-Synuclein K58N Missense Variant in a Patient with Parkinson's Disease.
Al-Azzani M et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2025
Alpha-Synuclein Neurobiology in Parkinson's Disease: A Comprehensive Review of Its Role, Mechanisms, and Therapeutic Perspectives.
Pitton Rissardo J et al.
Brain Sciences, 2025
Molecular Dynamics Study of α-Synuclein Domain Deletion Mutant Monomers.
Onishi N et al.
Biomolecules, 2025
Protein aggregation in neurodegenerative diseases.
Wang J et al.
Chinese Medical Journal, 2025
Oxidative modification of methionine residue in α-synuclein by dopamine induces cellular vulnerability, oligomerization and secretion of α-synuclein.
Kato Y et al.
Journal of Clinical Biochemistry and Nutrition, 2025
In situ exogenous alpha-synuclein aggregates inhibit murine ventricular voltage-gated inward sodium and outward potassium currents.
Lee B et al.
Journal of Parkinson's Disease, 2025
Parkinson disease is a fatty acidopathy.
Fanning S et al.
Nature Reviews. Neurology, 2025
Brain region-specific and systemic transcriptomic alterations in a human alpha-synuclein overexpressing rat model.
Hoof V et al.
Aging, 2025
Alpha-synuclein inclusions reduced by PIKfyve inhibition in Parkinson disease cell models.
Lucas-Del-Pozo S et al.
Neurobiology of Disease, 2025
Decreased SNCA expression in whole-blood RNA analysis of Parkinson's disease adjusting for neutrophils.
Xu KY et al.
Npj Parkinson's Disease, 2025
Carbamylation Promotes Sequence-Specific Amyloidogenesis in the α-Synuclein KTKEGV Repeat Motifs.
Gadhavi J et al.
Acs Chemical Neuroscience, 2025
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases.
Feringa FM et al.
Nature Metabolism, 2025
Genetic and structural aspects of amyloid diseases.
Rosenberg GM et al.
Science Translational Medicine, 2025
A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features.
Brücke C et al.
Molecular Neurodegeneration, 2025
Molecular Dynamics Simulations Reveal Conformational Determinants of the Dynamic Association between α-Synuclein and Membranes.
Huang J et al.
Journal of Chemical Information and Modeling, 2025
Modeling Synucleinopathy Using hESC-Derived Cerebral Organoids.
Kim SJ et al.
Cells, 2025
Conformational Ensemble Dynamics of Intrinsically Disordered Full-Length α- and β-Synuclein Monomers.
Lv Z et al.
Journal of Chemical Information and Modeling, 2025
Alternative pre-mRNA Splicing and Gene Expression Patterns in Midbrain Lineage Cells Carrying Familial Parkinson's Disease Mutations.
Lee YJ et al.
Biorxiv : the Preprint Server for Biology, 2025
Hypoxia and TTR dysregulation in astrocytes from Parkinson's disease with a specific mitochondrial haplogroup: A single-cell analysis.
Wang J et al.
Neural Regeneration Research, 2025
Parkinson's disease: genetics and neuroinflammatory insights.
Chandel I et al.
Inflammopharmacology, 2025
Isobavachalcone inhibits α-synuclein fibrillogenesis and its Parkinson's disease variants, disassembles the mature fibrils and alleviates cellular toxicity.
Xie F et al.
International Journal of Biological Macromolecules, 2025
Interaction Between α-Synuclein and DJ-1 in Parkinson's Disease.
Sobhifar P et al.
Brain Sciences, 2025
α-Synuclein Drives SNARE-Dependent Tubular Remodeling of Vesicles.
Li Q et al.
Journal of the American Chemical Society, 2025
Alpha-synuclein fibril structures cluster into distinct classes.
Milchberg MH et al.
Biophysical Journal, 2025
Alpha-synuclein interacts with regulators of ATP homeostasis in mitochondria.
Serdiuk T et al.
Nature Communications, 2025