Associated Papers
In vitro-prepared A30P alpha-synuclein fibrils adopt the conserved and disease-relevant Greek key fold.
Milchberg MH et al.
Biorxiv : the Preprint Server for Biology, 2026
The Yeast Parkinson's Disease Model Exhibits An Increase in Peroxisome Number Independent of the Division Proteins Vps1 and Dnm1.
Sarhadi TR et al.
Molecular Neurobiology, 2025
Interaction Between α-Synuclein and DJ-1 in Parkinson's Disease.
Sobhifar P et al.
Brain Sciences, 2025
Unveiling the significance of synaptic proteins in parkinson's pathogenesis: A review.
Soni R et al.
International Journal of Biological Macromolecules, 2025
Analysis and comparison of post-translational modifications of α-synuclein filaments in multiple system atrophy and dementia with Lewy bodies.
Kametani F et al.
Scientific Reports, 2024
Expert Commentary: A new genetic variant, presenting as young onset rapidly progressive dementia and parkinsonism.
Uribe Roca MC
Parkinsonism & Related Disorders, 2024
Interplay between α-synuclein and parkin genes: Insights of Parkinson's disease.
Sharma K et al.
Molecular Biology Reports, 2024
Resequencing the complete SNCA locus in Indian patients with Parkinson's disease.
Kishore A et al.
Npj Parkinson's Disease, 2024
Liquid-liquid phase separation of α-synuclein is highly sensitive to sequence complexity.
Mahapatra A et al.
Protein Science : a Publication of the Protein Society, 2024
In silico analysis of alpha-synuclein protein variants and posttranslational modifications related to Parkinson's disease.
da Silva ANR et al.
Journal of Cellular Biochemistry, 2024
Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease.
Muwanigwa MN et al.
Molecular and Cellular Neurosciences, 2024
Genetics of Parkinson's Disease: state-of-the-art and role in clinical settings.
Dulski J et al.
Neurologia I Neurochirurgia Polska, 2024
The interaction between alpha-synuclein and mitochondrial dysfunction in Parkinson's disease.
Li HY et al.
Biophysical Chemistry, 2023
Liquid-liquid phase separation of α-synuclein is highly sensitive to sequence complexity.
Mahapatra A et al.
Biorxiv : the Preprint Server for Biology, 2023
Transcriptional mutagenesis of α-synuclein caused by DNA oxidation in Parkinson's disease pathogenesis.
Basu S et al.
Acta Neuropathologica, 2023
In Silico Evaluation of the Potential Association of the Pathogenic Mutations of Alpha Synuclein Protein with Induction of Synucleinopathies.
Elnageeb ME et al.
Diseases (basel, Switzerland), 2023
Parkinson's disease - genetic cause.
Cherian A et al.
Current Opinion in Neurology, 2023
Sporadic SNCA mutations A18T and A29S exhibit variable effects on protein aggregation, cell viability and oxidative stress.
Joshi N et al.
Molecular Biology Reports, 2023
Discerning Modulation of α-Synuclein Amyloid Assembly by α-Crystallin.
Pippal B et al.
Acs Chemical Neuroscience, 2023
Single point mutations at the S129 residue of α-synuclein and their effect on structure, aggregation, and neurotoxicity.
Pandit E et al.
Frontiers in Chemistry, 2023
Effects of Mutations and Post-Translational Modifications on α-Synuclein In Vitro Aggregation.
Pancoe SX et al.
Journal of Molecular Biology, 2022
Human Induced Pluripotent Stem Cell Phenotyping and Preclinical Modeling of Familial Parkinson's Disease.
Kim J et al.
Genes, 2022
Mechanisms of enhanced aggregation and fibril formation of Parkinson's disease-related variants of α-synuclein.
Ohgita T et al.
Scientific Reports, 2022
A new alpha-synuclein missense variant (Thr72Met) in two Turkish families with Parkinson's disease.
Fevga C et al.
Parkinsonism & Related Disorders, 2021
Targeted attenuation of elevated histone marks at SNCA alleviates α-synuclein in Parkinson's disease.
Guhathakurta S et al.
Embo Molecular Medicine, 2021
Reverse engineering Lewy bodies: how far have we come and how far can we go?
Fares MB et al.
Nature Reviews. Neuroscience, 2021
Genetics of Parkinson's disease in the Polish population.
Milanowski ŁM et al.
Neurologia I Neurochirurgia Polska, 2021
Genetic Analysis and Literature Review of SNCA Variants in Parkinson's Disease.
Guo Y et al.
Frontiers in Aging Neuroscience, 2021
Alpha-Synuclein Aggregation in Parkinson's Disease.
Srinivasan E et al.
Frontiers in Medicine, 2021
Cognitive Impairment in Genetic Parkinson's Disease.
Planas-Ballvé A et al.
Parkinson's Disease, 2021
Possible Role of Amyloidogenic Evolvability in Dementia with Lewy Bodies: Insights from Transgenic Mice Expressing P123H β-Synuclein.
Fujita M et al.
International Journal of Molecular Sciences, 2020
Pathogenic Mutations Differentially Regulate Cell-to-Cell Transmission of α-Synuclein.
Guan Y et al.
Frontiers in Cellular Neuroscience, 2020
Common genetic variants associated with Parkinson's disease display widespread signature of epigenetic plasticity.
Sharma A et al.
Scientific Reports, 2019
Neuronal microtubules and proteins linked to Parkinson's disease: a relevant interaction?
Calogero AM et al.
Biological Chemistry, 2019
Different Effects of α-Synuclein Mutants on Lipid Binding and Aggregation Detected by Single Molecule Fluorescence Spectroscopy and ThT Fluorescence-Based Measurements.
Ruf VC et al.
Acs Chemical Neuroscience, 2019
The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson's Diseases.
Zhang J et al.
Frontiers in Neuroscience, 2019
Comparison of Kinetics, Toxicity, Oligomer Formation, and Membrane Binding Capacity of α-Synuclein Familial Mutations at the A53 Site, Including the Newly Discovered A53V Mutation.
Mohite GM et al.
Biochemistry, 2018
Genetics of Synucleinopathies.
Nussbaum RL
Cold Spring Harbor Perspectives in Medicine, 2018
Role of Sporadic Parkinson Disease Associated Mutations A18T and A29S in Enhanced α-Synuclein Fibrillation and Cytotoxicity.
Kumar S et al.
Acs Chemical Neuroscience, 2018
Pore-Forming Proteins as Mediators of Novel Epigenetic Mechanism of Epilepsy.
Surguchov A et al.
Frontiers in Neurology, 2017
Genetic Variants in SNCA and the Risk of Sporadic Parkinson's Disease and Clinical Outcomes: A Review.
Campêlo CLDC et al.
Parkinson's Disease, 2017
A53T in a parkinsonian family: a clinical update of the SNCA phenotypes.
Tambasco N et al.
Journal of Neural Transmission (vienna, Austria : 1996), 2016
The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease.
Benskey MJ et al.
Journal of Neurochemistry, 2016
Phenotypic spectrum of alpha-synuclein mutations: New insights from patients and cellular models.
Petrucci S et al.
Parkinsonism & Related Disorders, 2016
Identification of synaptosomal proteins binding to monomeric and oligomeric α-synuclein.
Betzer C et al.
Plos One, 2015
Role of genomics in translational research for Parkinson's disease.
Sekiyama K et al.
Biochemical and Biophysical Research Communications, 2014
Genetic variants and animal models in SNCA and Parkinson disease.
Deng H et al.
Ageing Research Reviews, 2014
Update on novel familial forms of Parkinson's disease and multiple system atrophy.
Fujioka S et al.
Parkinsonism & Related Disorders, 2014