Associated Papers
CDK5 Inhibits Synphilin-1 Ubiquitination and Basal Mitophagy: Implications for Parkinson's Disease.
Savyon M et al.
International Journal of Molecular Sciences, 2025
Co-occurrence of Parkinson's disease and Retinitis Pigmentosa: A genetic and in silico analysis.
Dwivedi A et al.
Neuroscience, 2025
Combining germline, tissue and liquid biopsy analysis by comprehensive genomic profiling to improve the yield of actionable variants in a real-world cancer cohort.
Vanni I et al.
Journal of Translational Medicine, 2024
Sequence and Structure-Based Analyses of Human Ankyrin Repeats.
Chakrabarty B et al.
Molecules (basel, Switzerland), 2022
KIR2DL5 mutation and loss underlies sporadic dermal neurofibroma pathogenesis and growth.
Anastasaki C et al.
Oncotarget, 2017
The New Immortalized Uroepithelial Cell Line HBLAK Contains Defined Genetic Aberrations Typical of Early Stage Urothelial Tumors.
Hoffmann MJ et al.
Bladder Cancer (amsterdam, Netherlands), 2016
The Protein Complex of Neurodegeneration-related Phosphoinositide Phosphatase Sac3 and ArPIKfyve Binds the Lewy Body-associated Synphilin-1, Preventing Its Aggregation.
Ikonomov OC et al.
The Journal of Biological Chemistry, 2015
Next-generation sequencing of salivary high-grade neuroendocrine carcinomas identifies alterations in RB1 and the mTOR pathway.
Goyal B et al.
Experimental and Molecular Pathology, 2014
Parkinson's disease: from genetics to treatments.
Fan HC et al.
Cell Transplantation, 2013
Genetically engineered mouse models of Parkinson's disease.
Crabtree DM et al.
Brain Research Bulletin, 2012
The Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formation.
Tsai YC et al.
Plos One, 2012
Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.
Alvarez-Castelao B et al.
Cellular and Molecular Life Sciences : Cmls, 2011
Identification of Parkinson's disease candidate genes using CAESAR and screening of MAPT and SNCAIP in South African Parkinson's disease patients.
Keyser RJ et al.
Journal of Neural Transmission (vienna, Austria : 1996), 2011
Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner.
Büttner S et al.
Plos One, 2010
Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model.
Smith WW et al.
Human Molecular Genetics, 2010
Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease.
Soehn AS et al.
Neurogenetics, 2010
Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice.
Nuber S et al.
Neurogenetics, 2010
Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors.
Krenz A et al.
Journal of Neurochemistry, 2009
Genes associated with Parkinson syndrome.
Biskup S et al.
Journal of Neurology, 2008
Microarray expression analysis reveals genetic pathways implicated in C621 synphilin-1-mediated toxicity.
Bonin M et al.
Journal of Neural Transmission (vienna, Austria : 1996), 2008
Genetic association study of synphilin-1 in idiopathic Parkinson's disease.
Myhre R et al.
Bmc Medical Genetics, 2008
Synphilin-1 isoforms in Parkinson's disease: regulation by phosphorylation and ubiquitylation.
Szargel R et al.
Cellular and Molecular Life Sciences : Cmls, 2008
The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease.
Marx FP et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2007
Genetics of Parkinson's disease and parkinsonism.
Douglas MR et al.
Expert Review of Neurotherapeutics, 2007
Mutation analysis of the seven in absentia homolog 1 (SIAH1) gene in Parkinson's disease.
Franck T et al.
Journal of Neural Transmission (vienna, Austria : 1996), 2006
alpha-Synuclein is colocalized with 14-3-3 and synphilin-1 in A53T transgenic mice.
Shirakashi Y et al.
Acta Neuropathologica, 2006
Interactions of Synphilin-1 with phospholipids and lipid membranes.
Takahashi T et al.
Febs Letters, 2006
Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway.
Giaime E et al.
The Journal of Biological Chemistry, 2006
Parkin and defective ubiquitination in Parkinson's disease.
Dawson TM
Journal of Neural Transmission. Supplementum, 2006
The role of synphilin-1 in synaptic function and protein degradation.
Krüger R
Cell and Tissue Research, 2004
Parkin-associated Parkinson's disease.
von Coelln R et al.
Cell and Tissue Research, 2004
Genetic contributions to Parkinson's disease.
Huang Y et al.
Brain Research. Brain Research Reviews, 2004
Unraveling the pathogenesis of Parkinson's disease--the contribution of monogenic forms.
Bonifati V et al.
Cellular and Molecular Life Sciences : Cmls, 2004
Screening for mutations in synaptotagmin XI in Parkinson's disease.
Glass AS et al.
Journal of Neural Transmission. Supplementum, 2004
Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.
Marx FP et al.
Human Molecular Genetics, 2003
Spectrum of phenotypes and genotypes in Parkinson's disease.
Riess O et al.
Journal of Neurology, 2002