Associated Papers
Cytoplasmic TDP-43 leads to early behavioral impairments without neurodegeneration in a serotonergic neuron-specific C. elegans model.
Lacour A et al.
Scientific Reports, 2026
Clinical trajectories and genetic profiles of SOD1-related amyotrophic lateral sclerosis: insights from a single-center cohort in India.
Keerthipriya MS et al.
Journal of Neurology, 2026
Early brain-wide disruption of sleep microarchitecture in amyotrophic lateral sclerosis.
Lang C et al.
The Journal of Clinical Investigation, 2026
SOD1 mutations in Taiwanese ALS patients: Clinical characteristics, frequency, and a p.T138R founder effect.
Jih KY et al.
Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2025
CRISPR/Cas9 a genomic engineering technology for treatment in ALS mouse models.
Khan H et al.
Regenerative Therapy, 2025
SLP2/PHB Aggregates in ALS Mouse Models and Patients: Implications Beyond CHCHD10-Associated Motor Neuron Disease.
Genin EC et al.
International Journal of Molecular Sciences, 2025
Does Amyotrophic Lateral Sclerosis (ALS) Have Metabolic Causes from Human Evolution?
Spedding M
Cells, 2025
Oxidative denaturation of Cu/Zn-superoxide dismutase associated with neurodegenerative diseases.
Yoshida M et al.
Protein Science : a Publication of the Protein Society, 2025
Landscapes of missense variant impact for human superoxide dismutase 1.
Axakova A et al.
American Journal of Human Genetics, 2025
Identification of disease-associated molecular signatures in the Prp-TDP-43A315T mouse model of ALS: Toward preclinical biomarker development.
Al Ojaimi Y et al.
Journal of Neuropathology and Experimental Neurology, 2025
Genetic architecture of amyotrophic lateral sclerosis: a comprehensive review.
Yuan L et al.
Journal of Genetics and Genomics = Yi Chuan Xue Bao, 2025
Diverse effects of coexpression of human SOD1 variants on motor neuron disease.
Tokuda E et al.
Human Molecular Genetics, 2025
Novel Dual Mechanism GRT-X Agonist Acting on Kv7 Potassium Channel/Translocator Protein Receptor Prevents Motoneuron Degeneration Following Exposure to Mouse and Human Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Astrocyte-Conditioned Media.
Masegosa VM et al.
Acs Chemical Neuroscience, 2025
Deciphering hypothalamic pathology in ALS: insights into non-motor symptoms and disease progression.
Chang J et al.
Ebiomedicine, 2025
Genetically Predict Diet-derived Antioxidants and Risk of Neurodegenerative Diseases Among Individuals of European Descent: A Mendelian Randomization Study.
Duan QQ et al.
Brain and Behavior, 2025
Cytoplasmic TDP-43 leads to early functional impairments without neurodegeneration in a Serotonergic Neuron-Specific C. elegans Model.
Lacour A et al.
Biorxiv : the Preprint Server for Biology, 2025
Role of copper in central nervous system physiology and pathology.
Locatelli M et al.
Neural Regeneration Research, 2025
Exploring epigenetic modifications as potential biomarkers and therapeutic targets in amyotrophic lateral sclerosis.
Hou X et al.
Journal of Neurology, 2025
CREB3 gain of function variants protect against ALS.
Megat S et al.
Nature Communications, 2025
Artificial enforcement of the unfolded protein response reduces disease features in multiple preclinical models of ALS/FTD.
Valenzuela V et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy, 2025
Integrated transcriptomic profiling reveals a STING-mediated Type II Interferon signature in SOD1-mutant amyotrophic lateral sclerosis models.
Hiew JY et al.
Communications Biology, 2025
Landscapes of missense variant impact for human superoxide dismutase 1.
Axakova A et al.
Biorxiv : the Preprint Server for Biology, 2025
Brown Adipose Tissue undergoes pathological perturbations and shapes C2C12 myoblast homeostasis in the SOD1-G93A mouse model of Amyotrophic Lateral Sclerosis.
Rosina M et al.
Heliyon, 2025
Metabolic rate and insulin-independent glucose uptake increase in a TDP-43Q331K mouse model of amyotrophic lateral sclerosis.
McDonald TS et al.
Heliyon, 2025
The Ile35 Residue of the ALS-Associated Mutant SOD1 Plays a Crucial Role in the Intracellular Aggregation of the Molecule.
Asai Y et al.
Molecular Neurobiology, 2025
GDF15-GFRAL signaling drives weight loss and lipid metabolism in mouse model of amyotrophic lateral sclerosis.
Cocozza G et al.
Brain, Behavior, and Immunity, 2025
Schwann Cells in Neuromuscular Disorders: A Spotlight on Amyotrophic Lateral Sclerosis.
Moss KR et al.
Cells, 2025
Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients: a rare occurrence?
Martinelli I et al.
Neural Regeneration Research, 2025
A variant of the Hspa8 synaptic chaperone modifies disease in a SOD1G86R mouse model of amyotrophic lateral sclerosis.
Takeda T et al.
Experimental Neurology, 2025
The role of autophagy in the pathogenesis and treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Beckers J et al.
Autophagy Reports, 2025
A systematic review and functional in-silico analysis of genes and variants associated with amyotrophic lateral sclerosis.
Arreola-Aldape CA et al.
Frontiers in Neuroscience, 2025
Clinical characterization of common pathogenic variants of SOD1-ALS in Germany.
Wiesenfarth M et al.
Journal of Neurology, 2024
Expression Changes of miRNAs in Humans and Animal Models of Amyotrophic Lateral Sclerosis and Their Potential Application for Clinical Diagnosis.
Wang R et al.
Life (basel, Switzerland), 2024
Amyotrophic lateral sclerosis patients with various gene mutations show diverse motor phenotypes and survival in China.
Jiang Q et al.
Journal of Medical Genetics, 2024
ALS Identified: two-year findings from a sponsored ALS genetic testing program.
Goutman SA et al.
Annals of Clinical and Translational Neurology, 2024
Trehalose Protects against Superoxide Dismutase 1 Proteinopathy in an Amyotrophic Lateral Sclerosis Model.
Magalhães RSS et al.
Antioxidants (basel, Switzerland), 2024
Variability in SOD1-associated amyotrophic lateral sclerosis: geographic patterns, clinical heterogeneity, molecular alterations, and therapeutic implications.
Huang M et al.
Translational Neurodegeneration, 2024
Cortical hyperexcitability in mouse models and patients with amyotrophic lateral sclerosis is linked to noradrenaline deficiency.
Scekic-Zahirovic J et al.
Science Translational Medicine, 2024
Unraveling the Heterogeneity of ALS-A Call to Redefine Patient Stratification for Better Outcomes in Clinical Trials.
Tzeplaeff L et al.
Cells, 2024
Functional consequences of familial ALS-associated SOD1L84F in neuronal and muscle cells.
Verma S et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2024