Varaico: Literature-Extracted Genetic Variants

Gene:SOS1
Variant:p.Q4H
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SOS1

NM_005633.4:p.Q4H

Associated Papers

Conformations of KRAS4B Affected by Its Partner Binding and G12C Mutation: Insights from GaMD Trajectory-Image Transformation-Based Deep Learning.

Chen J et al.

Journal of Chemical Information and Modeling, 2024

Mesonephric-like adenocarcinoma of the female genital tract: possible role of KRAS-targeted treatment-detailed molecular analysis of a case series and review of the literature for targetable somatic KRAS-mutations.

Brambs CE et al.

Journal of Cancer Research and Clinical Oncology, 2023

Translational relevance of SOS1 targeting for KRAS-mutant colorectal cancer.

Alem D et al.

Molecular Carcinogenesis, 2023

SOS1-inspired hydrocarbon-stapled peptide as a pan-Ras inhibitor.

Li A et al.

Bioorganic Chemistry, 2023

Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition.

Wei W et al.

The Journal of Experimental Medicine, 2023

36820830 (PubMed )
Supplement: JEM_20221563_TableS3.xlsx › Driver_mutations

Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape.

Ratnasinghe BD et al.

Biorxiv : the Preprint Server for Biology, 2023

Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape.

Ratnasinghe BD et al.

Computational and Structural Biotechnology Journal, 2023

Normal Mode Analysis of KRas4B Reveals Partner Specific Dynamics.

Eren M et al.

The Journal of Physical Chemistry. B, 2021

RAS as a positive predictive biomarker: focus on lung and colorectal cancer patients.

Malapelle U et al.

European Journal of Cancer (oxford, England : 1990), 2021

Genomic profiling of primary histiocytic sarcoma reveals two molecular subgroups.

Egan C et al.

Haematologica, 2020

Photocontrol of the GTPase activity of the small G protein K-Ras by using an azobenzene derivative.

Iwata S et al.

Biochemistry and Biophysics Reports, 2015

Kinetic mechanisms of mutation-dependent Harvey Ras activation and their relevance for the development of Costello syndrome.

Wey M et al.

Biochemistry, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."